Herbicidal 2-(1H)-pyrazinones

ABSTRACT

This invention relates to a novel class of 2-(1H)-pyrazinones and their use as herbicides and plant growth regulants.

BACKGROUND OF THE INVENTION

Czechoslovakian Pat. No. 225,881 discloses herbicidal sulfonylureas ofthe formula ##STR1## wherein R₂ is CH₃, CF₃ or NO₂.

U.S. Pat. No. 4,169,719 and U.S. Pat. No. 4,127,405 disclose, in part,herbicidal benzenesulfonylureas of the formulae ##STR2## wherein R₃ isH, F, Cl, Br, I, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, NO₂, CF₃, CN, S(O)_(n) CH₃or S(O)_(n) CH₂ CH₃ ; and

R₄ is H, F, Cl, Br, C₁ -C₂ alkyl or C₁ -C₂ alkoxy.

U.S. Pat. No. 4,394,506 discloses, in part, herbicidalbenzenesulfonylureas of the formula ##STR3## wherein Q is O, S or NR₆.

U.S. Pat. No. 4,420,325 discloses, in part, herbicidalbenzylsulfonylureas of the formula ##STR4## wherein R₁ is F, Cl, Br,CF₃, C₁ -C₃ alkoxy, C₁ -C₃ alkyl, NO₂, CO₂ R₄, SO₂ R₅, SO₂ NR₆ R₇, SO₂N(OCH₃)CH₃, SO₂ CH₂ CF₃ or OSO₂ R₅.

U.S. Pat. No. 4,481,029 discloses, in part, herbicidalthiophenesulfonylureas of the formula ##STR5## wherein A' is H, Cl, Br,C₁ -C₄ alkyl, OCH₃, NO₂ or CF₃ ;

A is C(O)QR^(I) or C(T)R^(II) ;

Q is O, S or NR₆ ; and

T is O or ═NOR^(III).

EP-A-13,480 discloses, in part, herbicidal pyridine sulfonylureas of theformula ##STR6## wherein R₁ is H, Cl, Br, F, C₁ -C₄ alkyl, C₁ -C₄alkoxy, C₁ -C₄ alkylthio, NO₂ or CO₂ R₅.

EP-A-95,925 discloses, in part, herbicidal pyrazole sulfonylureas of theformula ##STR7## wherein ##STR8##

U.S. Pat. No. 4,511,392 and U.S. Pat. No. 4,465,505 disclose herbicidalbenzenesulfonylureas where the ortho substituent is a 5-memberedheterocycle.

U.S. Pat. No. 4,460,401 and U.S. Pat. No. 4,494,980 disclose herbicidalbenzenesulfonylureas where the ortho substituent is a 5- or 6-memberedheterocycle.

U.S. Pat. No. 4,514,211 discloses, in part, herbicidal sulfonylureas ofthe formula ##STR9## wherein Q is O, S, SO or SO₂.

U.S. Pat. No. 4,586,950 discloses, in part, herbicidal sulfonyluras ofthe formula ##STR10## wherein J is ##STR11##

U.S. Pat. No. 4,589,911 discloses herbicidal sulfonylureas of theformula ##STR12##

SUMMARY OF THE INVENTION

This application pertains to novel compounds of Formula I,agriculturally suitable compositions containing them and theirmethod-of-use as preemergent and/or postemergent herbicides or plantgrowth regulants. ##STR13## wherein R is H or CH₃ ;

X is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, NH₂, NHCH₃ or N(CH₃)₂ ;

Y is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₂ alkylthio, Cl or Br;

Z is CH, N, CF, CCl or CBr;

J is ##STR14## R₁ is F, Cl, Br, NO₂, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₃-C₄ cycloalkyl, C₂ -C₄ haloalkenyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₂-C₄ alkoxyalkoxy, CO₂ R_(a), C(O)NR_(b) R_(c), SO₂ NR_(d) R_(e),S(O)_(n) R_(f), C(O)R_(g), CH₂ CN or L;

R₂ is H, F, Cl, Br, CN, CH₃, OCH₃, SCH₃ or OCF₂ H;

R₃ is Cl, NO₂, CO₂ CH₃, CO₂ CH₂ CH₃, SO₂ N(CH₃)₂, SO₂ CH₃, SO₂ CH₂ CH₃,OCH₃, or OCH₂ CH₃ ;

R_(a) is C₁ -C₃ alkyl optionally substituted by halogen, C₁ -C₂ alkoxyor CN, allyl or propargyl;

R_(b) is H, C₁ -C₃ alkyl or C₁ -C₂ alkoxy;

R_(c) is C₁ -C₂ alkyl;

R_(d) is H, C₁ -C₃ alkyl, C₁ -C₂ alkoxy, allyl or cyclopropyl;

R_(e) is H or C₁ -C₃ alkyl;

R_(f) is C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, allyl or propargyl;

R_(g) is C₁ -C₄ alkyl, C₁ -C₄ haloalkyl or C₃ -C₅ cycloalkyl optionallysubstituted by halogen;

n is 0, 1 or 2;

L is ##STR15## R_(h) is H or CH₃ ; R_(i) is H or CH₃ ;

R_(j) is H, CH₃ or CH₂ CH₃ ;

R_(k) is H, CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, SCH₃ or SCH₂ CH₃ ;

R_(m) is H, CH₃ or CH₂ CH₃ ;

R_(n) is H or CH₃ ;

R₄ is C₁ -C₃ alkyl, C₁ -C₂ haloalkyl, C₁ -C₂ alkoxy, C₂ -C₄ haloalkenyl,F, Cl, Br, NO₂, CO₂ R_(a), C(O)NR_(b) R_(c), SO₂ NR_(d) R_(e), S(O)_(n)R_(f), C(O)R_(g) or L;

R₅ is H, F, Cl, Br or CH₃ ;

R₆ is C₁ -C₃ alkyl, C₁ -C₂ alkoxy, C₂ -C₄ haloalkenyl, F, Cl, Br, CO₂R_(a), C(O)NR_(b) R_(c), SO₂ NR_(d) R_(e), S(O)_(n) R_(f), C(O)R_(g) orL;

R₇ is H, F, Cl or CH₃ ;

R₈ is H or C₁ -C₃ alkyl;

R₉ is C₁ -C₃ alkyl, C₁ -C₂ alkoxy, F, Cl, Br, NO₂, CO₂ R_(a), SO₂ NR_(d)R_(e), S(O)_(n) R_(f), OCF₂ H, C(O)R_(g), C₂ -C₄ haloalkenyl or L;

R₁₀ is H, Cl, F, Br, C₁ -C₃ alkyl or C₁ -C₂ alkoxy;

R₁₁ is H or C₁ -C₂ alkyl;

R₁₂ is H or C₁ -C₂ alkyl;

R₁₃ is H, C₁ -C₆ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkoxyalkyl, C₃ -C₅cycloalkyl or C₄ -C₆ cycloalkylalkyl;

R₁₄ is H, F, Cl, Br, CN, CH₃, OCH₃, SCH₃ or OCF₂ H; and

Q is O, S, SO, SO₂ or C(O);

and their agriculturally suitable salts; provided that X and Y are notsimultaneously H.

In the above definitions, the term "alkyl", used either alone or incompound words such as "haloalkyl", denotes straight chain or branchedalkyl, e.g. methyl, ethyl, n-propyl, isopropyl or the different butyl,pentyl or hexyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propyloxy, isopropyloxy and thedifferent butyl isomers.

Alkenyl denotes straight chain or branched alkenes, e.g. vinyl,1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.

Cycloalkyl denotes cyclopropyl or cyclobutyl.

The term "haloalkyl" denotes an alkyl group substituted by fluorine,chlorine, bromine or iodine.

In terms such as C₂ -C₄ alkoxyalkoxy, the specified number of carbonatoms is meant to define the total number of carbon atoms in thatsubstituent group. For example, C₂ -C₄ alkoxyalkoxy would represent OCH₂OCH₃ through O(CH₂)₃ OCH₃ or OCH₂ OCH₂ CH₃ and the various structuralisomers embraced therein.

Preferred for reasons of their higher herbicidal activity, greater plantgrowth regulant activity or more favorable ease of synthesis are:

1. Compounds of Formula I wherein Z is CH.

2. Compounds of Preferred 1 where

X is CH₃, CH₂ CH₃, OCH₃ or OCH₂ CH₃ ; and

Y is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, SCH₃, SCH₂ CH₃, Cl or Br.

3. Compounds of Preferred 2 where

R₁ is Cl, NO₂, CH₃, CH₂ CH₃, C₁ -C₂ haloalkyl, cyclopropyl, C₂ -C₃haloalkenyl, OCH₃, OCH₂ CH₃, C₁ -C₂ haloalkoxy, CO₂ R_(a), C(O)NR_(b)R_(c), SO₂ NR_(d) R_(e), S(O)_(n) R_(f), C(O)R_(g), CH₂ CN or L;

R_(b) is H, CH₃ or OCH₃ ;

R_(c) is CH₃ ;

R_(d) is H, CH₃ or OCH₃ ;

R_(e) is CH₃ ;

R_(f) is CH₃ or CH₂ CH₃ ;

R_(g) is CH₃, CH₂ CH₃ or cyclopropyl;

n is 0 or 2;

R₄ is CH₃, CH₂ CH₃, Cl, Br, NO₂, CO₂ R_(a), C(O)NR_(b) R_(c), SO₂ NR_(d)R_(e), S(O)_(n) R_(f) or C(O)R_(g) ;

R₅ is H;

R₆ is CH₃, CH₂ CH₃, OCH₃, Cl, Br, CO₂ R_(a), C(O)NR_(b) R_(c), SO₂NR_(d) R_(e), S(O)_(n) R_(f) or C(O)R_(g) ;

R₇ is H;

R₈ is CH₃ ;

R₉ is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, Cl, Br, NO₂, CO₂ R_(a), SO₂ NR_(d)R_(e) or S(O)_(n) R_(f) ;

R₁₀ is H, Cl, CH₃ or OCH₃ ; R₁₁ is H or CH₃ ; R₁₂ is H; and R₁₃ is H orC₁ -C₄ alkyl.

4. Compounds of Preferred 3 where J is J-1.

5. Compounds of Preferred 3 where J is J-2.

6. Compounds of Preferred 3 where J is J-3.

7. Compounds of Preferred 3 where J is J-4.

8. Compounds of Preferred 3 where J is J-5.

9. Compounds of Preferred 3 where J is J-6.

10. Compounds of Preferred 3 where J is J-7.

11. Compounds of Preferred 3 where J is J-8.

12. Compounds of Preferred 3 where J is J-9.

13. Compounds of Preferred 3 where J is J-10.

14. Compounds of Preferred 3 where J is J-11.

15. Compounds of Preferred 3 where J is J-12.

16. Compounds of Preferred 3 where J is J-13.

17. Compounds of Preferred 3 where J is J-14.

18. Compounds of Preferred 3 where J is J-15.

19. Compounds of Preferred 3 where J is J-16.

Specifically preferred for reasons of greatest ease of synthesis and/orgreatest herbicidal efficacy are:

2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinylamino)carbonylamino]sulfonyl]benzoicacid, methyl ester, m.p. 173°-176° C.; and

2-chloro-N-[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl)aminocarbonyl]benzenesulfonamide,m.p. 208-210.

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The compounds of Formula I can be prepared by one or more of thefollowing methods described below in Equations 1 to 5.

As shown in Equation 1 below, most compounds of Formula I can beprepared by reacting an appropriately substituted sulfonyl isocyanate ofFormula (1) with an appropriate amino or alkylamino pyrazinone ortriazinone of Formula (2). ##STR16## where J, R, X, Y and Z are aspreviously defined.

The reaction is best carried out in inert aprotic organic solvents suchas dichloromethane, 1,2-dichloroethane, tetrahydrofuran, oracetonitrile, at a temperature between 20° and 85° C. The order ofaddition is not critical; however, it is often convenient to add thesulfonyl isocyanate or a solution of it in the reaction solvent to astirred suspension of the amine.

Sulfonyl isocyanates (1) are generally prepared from the correspondingsulfonamides (3) (see Equations 17 and 18). In rare cases a sulfonamidemay not be sufficiently stable to be useful as an intermediate. In thesecases, as well as others, the requisite sulfonyl isocyanate (1) can bemade and reacted with the heterocyclic amine (2) by treating thecorresponding sulfonyl chloride with an isocyanate anion in the presenceof the amine (see Equation 5 and accompanying discussion).

In some cases, the desired product is insoluble in the reaction solventat ambient temperature and crystallizes from it in pure form. Productssoluble in the reaction solvent are isolated by evaporation of thesolvent. Compounds of Formula I then may be purified by trituration ofthe evaporation residue with solvents such as 1-chlorobutane or ethylether and filtration, by recrystallization from mixtures of solventssuch as 1,2-dichloroethane, 1-chlorobutane, and heptane or bychromatography on silica gel.

Some of the compounds of Formula I can be prepared as shown in Equation2. Reaction of a sulfonamide of Formula (3) with an appropriate methylpyrazinonyl carbamate or methyl triazinonyl carbamate of Formula (4) inthe presence of at least an equimolar amount of trimethylaluminum leadsto compounds of Formula I. ##STR17## where J, R, X, Y and Z are aspreviously defined; however, for this method R₂, R₃, R₄, R₆ and R₉cannot be CO₂ R_(a), C(O)NR_(b) R_(c), C(O)R_(g), L-1, or L-2, and Jcannot be J-13.

The reaction of Equation 2 is best run in either dichloromethane or1,2-dichloroethane solution at 20° to 85° C. for 10 to 96 hours under anitrogen or argon atmosphere. The product can be isolated by addition ofan aqueous acetic acid solution followed by extraction of the productinto dichloromethane, or by filtration of a product of low solubility.The product can be purified by trituration with solvents such as1-chlorobutane or ethyl ether, by recrystallization from mixtures ofsolvents such as 1,2-dichloroethane, 1-chlorobutane, and heptane, or bycolumn chromatography on silica gel.

Many of the compounds of Formula I can be prepared by the proceduresshown in Equation 3. ##STR18## where J, R, X, Y and Z are as defined forEquation 2.

The reactions shown in Equation 3 are carried out by contactingphenylcarbamates of Formula (5) with the aminoheterocycles of Formula(2) in an inert organic solvent such as dioxane or tetrahydrofuran attemperatures of about 20°-100° C. for a period of about one-half totwenty-four hours. The product can be isolated by evaporation of thereaction solvent and purified by methods previously described.

Phenyl carbamates of Formula (5) can be prepared by the methodsdescribed, or modifications thereof known to those skilled in the art,in European Patent Application No. 44,808 published Jan. 27, 1982; orSouth African Patent Application No. 825042.

Alternatively, many of the compounds of Formula I can be prepared by themethod described in Equation 4. ##STR19## where J, R, X, Y and Z are asdescribed for Equation 1, except that when R₂, R₄, R₆ or R₉ is CO₂R_(a), C(O)NR_(b) R_(c) or C(O)R_(g), R must be H.

The reaction in Equation 4 can be carried out by contacting equimolaramounts of a sulfonamide of Formula (3) with a heterocyclic phenylcarbamate of Formula (6) in the presence of an equimolar amount of1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), by methods analogous to thosedescribed in South African Patent Application No. 830441. The phenylcarbamates of Formula (6) can be prepared (from the corresponding aminesof Formula (2)) by methods, or modifications thereof known to thoseskilled in the art, described in South African Patent Application No.825671 and South African Patent Application No. 825045.

Rarely sulfonamides of Formula (3) may not be of sufficient stability tobe useful as starting materials in Equations 2 and 4, or asintermediates to the sulfonyl isocyanates (1) used in Equation 1 orsulfonyl carbamates (5) used in Equation 3. In these cases, as well asothers, the sulfonyl isocyanates (1) can be made as unisolatedintermediates by treating the corresponding sulfonyl chlorides ofFormula (7) with isocyanate anion in the presence of the heterocyclicamine of Formula (2). The amines react with the sulfonyl isocyanates asthey are formed to give the desired corresponding compounds of Formula I(Equation 5). ##STR20## where J, R, X, Y and Z are as previouslydefined.

The reaction is best carried out by adding over one to six hours asolution of at least one equivalent of a tetraalkylammonium isocyanate,such as tetra-n-butylammonium isocyanate, in a suitable aprotic organicsolvent, such as dichloromethane or tetrahydrofuran, to a well-stirredmixture of one equivalent of sulfonyl chloride (7) and at least oneequivalent of heterocyclic amine (2) in a similar suitable organicsolvent at 20°-40° C. The reaction mixture is then diluted withdichloromethane, washed with 1N sulfuric acid, and dried over sodiumsulfate. Rotary evaporation of the solvent leaves the product of FormulaI in crude form. This may be purified as has already been described forEquation 1.

Amino and alkylamino pyrazinones and triazinones of Formula (2) are madeby one or more of the following methods. ##STR21## where R, X, Y and Zare as initially defined; and

X₁ is Cl or Br.

A solution of halide (8) is reacted with at least two equivalents (onlytwo equivalents when Z is N and Y is Cl or Br) of the amine (9) at atemperature of 20° to 100° C. for 2 to 36 hours. Solvents like aqueousdioxane which dissolves both halide (8) and amine (9) are especiallyuseful.

The halides of Formula (8) where Y=X₁, may in turn be prepared by themethod shown in Equation 7. ##STR22## where X₁ and Z are as previouslydefined. When Z is CH, X is H, alkyl, alkoxy, NH₂, NHCH₃ or N(CH₃)₂, andwhen Z is N, X is H or alkyl.

In this method the cyanide (10) is treated with excess (typically 3-5equivalents) of the oxalyl halide (11) using the general conditionsdescribed by J. Vekemans, C. Pallers-Wieers, and G. Hoornaert (J.Heterocyclic Chem., 20, 919 (1983)).

Many of the halides of Formula (8) where Y is H, alkyl, or alkoxy can beprepared by the method described in Equation 8. ##STR23## where M is Li,Mg, Na or K;

X₁, X and Z are as defined for Equation 7; and

Y is H, alkyl, or alkoxy.

When Y is H, then MY (12) is LiAlH(OC₂ H₅)₃. M₁ is M and Y is H oralkyl, and M₁ is H when Y is alkoxy.

In this method (Equation 8) the cyanide of Formula (10) is converted tothe corresponding imine of Formula (13) by treatment with thenucleophilic reagent MY (12). When Y is alkoxy the transformation can becarried out by treating (10) with the appropriate alcohol (HY) in thepresence of a catalytic amount of the alkoxide MY (12) or an acid usinga variety of methods known in the art. See, for example, F. C. Schaeferand G. A. Peters, J. Org. Chem., 26, 412 (1961) and H. Watanabe, Y.Kikugawa, and S. Yamada, Chem. Pharm. Bull., 21, 465 (1973). The mixtureis then neutralized and the solvent evaporated to leave the imine (13).When Y is alkyl the transformation can be carried out by treating thecyanide (10) with two equivalents of the appropriate Grignard or lithiumreagent MY (12) in a hydrocarbon or ethereal solvent using a variety ofmethods well known in the art. For a review see C. A. Buehler and D. E.Pearson, Survey or Organic Syntheses, Wiley-Interscience, New York,1970, pp. 717-718. When Y is H, the transformation can be effected bytreating (10) with two equivalents of lithium triethoxyaluminohydride inether. Alternatively, diisobutylaluminum hydride may often besubstituted for the lithium triethoxyaluminohydride. These methods arereviewed in C. A. Buehler and D. E. Pearson Survey of Organic SynthesesVolume 2, Wiley-Interscience, New York, 1977, p. 500. Finally, theimines of Formula (13) are converted to the corresponding heterocyclesof Formula (8) using methodology analogous to that referenced for theconversion (10) to (8, Y=X₁) in Equation 7 (Equation 8b).

The oxalyl halides of Formula (11) are commercially available, and therequisite cyanides of Formula (10) are either known in the art or may bemade by a variety of methods known in the art. See for example, J. H.Boyer and J. Kooi, J. Am. Chem. Soc., 98, 1099 (1976); M. S. Bloom, D.S. Breslow, and C. R. Hauser, J. Am. Chem. Soc., 67, 539 (1945); H.Sakai, K. Ito and M. Sekiya, Chem. Pharm. Bull., 21, 2257 (1973); M.Masui, M. Suzuki and C. Yijima, J. Chem. Soc., 3958 (1964); K. Masuda,Y. Imashiro and T. Kaneko, Chem. Pharm. Bull., 18, 128 (1970); and thereferences cited therein.

The halides (8, X₁ =Cl) may be prepared in many cases from correspondingamines of Formula (2, R=H) as shown in Equation 9. ##STR24## where X, Yand Z are as initially defined, except that X cannot be NH₂ or NHCH₃.

In this method a solution of the amine (2, R=H) in concentratedhydrochloric acid is treated with sodium nitrite solution to give thechloro compound (8, X₁ =Cl) according to the general procedure of Beeand Rose (J. Chem. Soc. C., 2031 (1966)). This route is especiallyuseful when amines of Formula (2, R=H) are more readily prepared thanthe corresponding methylamines of Formula (2, R=CH₃).

The halides (8) where Z is CF, CCl or CBr are prepared from thecorresponding halides (8) where Z is CH as shown in Equation 10.##STR25## where X, X₁ and Y are as defined for Equation 6; and

Z₁ is F, Cl or Br.

In this method a solution of (8, Z=CH) in a solvent inert to thereacting halogen is treated with one equivalent of the halogen (dilutedwith nitrogen when Z₁ is F) at a temperature of -78° to 100° C. Themixture is then either heated to 100° C. to drive off the HZ by-product,or it is treated with a strong nonnucleophilic base likeN,N-diisopropylethylamine to remove the HZ₁ by-product.

Many of the amino and alkylamino pyrazinones and triazinones of Formula(2) where X is alkyl or NH₂ can be prepared from the correspondingpyrazinones and triazinones of Formula (2) where X is H as shown inEquation 11. ##STR26## where R, Y and Z are as initially defined. X inthe product (2) is alkyl or NH₂, and X₂ is Cl, Br, I, ##STR27##

In this method a solution or suspension of (2, X=H) is converted bytreatment with one equivalent of a strong base to the correspondingsalt. Representative base-solvent combinations include methyllithium intetrahydrofuran and sodium hydride in both this solvent and inN,N-dimethylformamide. The reaction is conducted between 20° and 60° C.The solution or suspension of the derived salt is then treated at 0°-60°C. with one equivalent of the alkylating or aminating agent XX₂ (14).When X is alkyl, X₂ is preferred to be I so as to maximize N-alkylation.When X is NH₂, X₂ is preferred to be 2,4,6-trimethylbenzenesulfonate or2,4,6-triisopropylbenzenesulfonate. The requisite alkylating andaminating reagents are known in the art, and many of them arecommercially available. After evaporation of the solvent the crudeproducts of Formula (2) can be purified by recrystallization orchromatography on silica gel. Compounds of Formula (2) where X is NH₂may be methylated to give corresponding compounds (2) where X isNHCH.sub. 3 or N(CH₃)₂ by a variety of general methods known in the art.

Many of the aminopyrazinones of Formula (2) where R is H, X is H, Y is Hor alkyl, and Z is CH can be prepared via the route described by G.Palamidassi for the case where Y is CH₃ (see Farmaco Ed. Sci., 18, 557(1963) and British Pat. No. 922,725 (Chem. Abstracts, 59, 10076h(1963)).

Some of the amino and methylaminotriazinones of Formula (2) where X isH, Y is H, alkyl or alkoxy and Z is N may be prepared from the known3,5,6-trichloro-1,2,4-triazine (15) as shown in Equation 12. ##STR28##where R is H or CH₃ ;

M₂ is Li, Mg, Na, K, Zn, Cd, Cu, or represents a combination of theseelements;

Y is alkoxy, alkyl, alkylthio or H (Y in (17) is a hydridoaluminatespecies when Y is H in (18); and

M₃ is Li, Na or K.

M₂ is M₃ when Y is alkoxy or alkylthio.

In this method the trichloro compound (15) is aminated to give (16)using the procedure described by H. Neunhoeffer and B. Lehmann for thereaction of (15) with dimethylamine (see Chem. Ber., 109, 1113 (1976))(Equation 12a).

Reaction conditions used in the next step (Equation 12b) depend upon thenature of Y. When Y is alkoxy, a solution of (16) in the appropriatealcohol HY and/or an inert solvent like benzene or tetrahydrofuran istreated with one equivalent of the alkoxide M₂ Y (17) at 0°-40° C.Evaporation of the solvent leaves a crude product that can be purifiedby recrystallization or chromatography on silica gel.

When Y is alkylthio, a solution of (16) in an inert solvent liketetrahydrofuran or glyme is treated with one equivalent of the thiolate(17) at -50° to 30° C. Evaporation of the solvent leaves a crude productthat can be purified by recrystallization or chromatography on silicagel.

When Y is alkyl, the reaction is conducted by reacting a solution orsuspension of (16) in an ethereal solvent with one of a variety ofalkyl-lithium, alkyl magnesium, alkyl zinc, alkyl cadmium, or cupratereagents known in the art either in the presence or absence of apalladium-based coupling catalyst. (For a couple of recent references toreactions of alkyl magnesium and alkyl zinc reagents in the presence ofa palladium-based coupling catalyst see T. Hayashi, M. Konishi, Y.Kobori, M. Kumada, T. Higuchi, K. Hirotsu, J. Am. Chem. Soc., 106, 158(1984) and E.-I. Negishi, H. Matsushita, M. Kobayashi, C. L. Rand,Tetrahedron Lett., 24, 3823 (1983)). When Y is H, the reaction issimilarly conducted by reacting a solution on suspension of (16) withone of a variety of hydridoaluminate reagents known in the art. Thecrude products (18) obtained upon evaporation of solvent are purified byrecrystallization or chromatography on silica gel.

Finally a solution or suspension of (18) in water is treated with oneequivalent of the hydroxide (19) at 40°-100° C. The solution is thencooled to room temperature and neutralized with a strong acid likeconcentrated hydrochloric acid. Evaporation of the water leaves (2, X=H,Z=N) contaminated with a little inorganic salt. If desired, the salt canbe removed from (2, X=H, Z=N) by recrystallization or columnchromatography (Equation 12c). The X substituent of these compounds (2,X=H, Z=N) can be elaborated as described in Equation 11.

Many of the amino and methylamino triazinones of Formula (2) where X isH, Y is H, alkyl, alkoxy, or alkylthio, and Z is N can be prepared viathe route described by H. Neunhoeffer and H. Hammann for the case whereR is NH₂ and Y is phenyl, employing modifications known to those trainedin the art (see Liebig's Ann. Chem., 283, (1984)). The X substituent ofthese compounds (2, Z=N) can then be elaborated as described in Equation11.

Some of the amino and methylamino pyrazinones and triazinones of Formula(2) where Y is alkoxy or alkyl and most of the amino and methylaminopyrazinones and triazinones of Formula (2) where Y is alkylthio can beprepared from the corresponding pyrazinones and triazinones where Y isCl or Br as shown in Equation 13. ##STR29## where R, X and Z are asinitially defined; and

M₂ and Y are as described for Equation 12.

The reaction conditions depend upon the nature of Y. When Y is alkoxy, asolution or suspension of (2, Y=Cl or Br) in the appropriate alcohol HYor an unreactive polar solvent like N,N-dimethylformamide is treatedwith at least one equivalent of the alkoxide M₂ Y (17) at a temperatureof 80° to 200° C. Such elevated temperatures may necessitate performingthe reaction at above ambient pressure. In some cases the presence of acyclic polyether like 18-crown-6 or a long chain polyester may provehelpful. When Y is alkylthio, a solution or suspension of (2, Y=Cl orBr) in a unreactive solvent like N,N-dimethylformamide is treated withat least one equivalent of the thiolate M₂ Y (17) at a temperature of80° to 150° C. When Y is alkyl the reaction is conducted as alreadydescribed for Equation 12b regarding the case where Y is alkyl. Theproducts (2, Y=alkoxy, alkylthio or alkyl) are isolated by evaporationof the solvent and purified by recrystallization or chromatography onsilica gel.

Finally, most of the amino and methylamino pyrazinones and triazinonesof Formula (2) where Y is H can be prepared from the correspondingpyrazinones and triazinones where Y is Cl or Br as shown in Equation 14.##STR30## where R, X and Z are as initially defined.

The reaction is carried out by treating the appropriate halide (2, Y=Clor Br) with hydrogen in the presence of a catalyst. For specificexamples of this type of reaction see H. Neunhoeffer and B. Lehmann,Chem. Ber., 109, 1113 (1976) and for a general review see P. N.Rylander, Catalytic Hydrogenation in Organic Syntheses, Academic Press,New York, 1979.

Heterocyclic intermediates of Formula (4) are made from thecorresponding free heterocycles (2, R=H) by the following method.##STR31## where X, Y and Z are as initially defined.

In this method, a solution or slurry of the appropriate heterocycle (2,R=H) in a suitable aprotic solvent (e.g., tetrahydrofuran, dioxane,glyme) at 0°-30° C. is treated with two equivalents of sodium hydride.After gas evolution ceases, the reaction mixture is treated with oneequivalent of dimethyl carbonate and stirred at 20°-30° C. for 8 to 24hours to provide a suspension of the sodium salt (20) (Equation 15a).

Sufficient concentrated hydrochloric acid is then added to bring the pHto 4. The mixture is saturated with sodium chloride and filtered. Theorganic layer is separated away from the aqueous layer, dried overmagnesium sulfate, and filtered. Evaporation of the solvent leaves thecarbamate (4, R=H) (Equation 15b).

Alternatively, the reaction mixture containing (20) formed in Equation15a is treated with at least two equivalents of iodomethane and thenheated at 60°-80° C. for 8 to 24 hours. The mixture is cooled andfiltered, and the solvent is evaporated. The residue is taken up indichloromethane, washed with water, and the solvent is evaporated,leaving the N-methyl carbamate (4, R=CH₃) (Equation 15c).

In some cases heterocycles of Formula (2) may be more easily preparedwith R being H than with R being CH₃. Many heterocycles (2, R=CH₃) canbe prepared from the corresponding heterocycles (2, R=H) by using themethod disclosed in Equation 9 followed by the method disclosed inEquation 6 or by using the method described in Equation 16 below.##STR32## where X, Y and Z are as defined in Equation 15.

In this method, the carbamate (4, R=CH₃) prepared from (2, R=H)(Equations 15a and 15c) is dissolved in anhydrous, alcohol-freechloroform saturated with propylene gas. Slightly more than oneequivalent (typically 1.1-1.2 equivalents) of iodotrimethylsilane isadded and the stirred solution is heated at 50°-60° C. for 2 to 4 hours.The mixture is cooled and two equivalents of methanol is added. Thesolvent is evaporated and the residue is taken up in methanol. Themixture is carefully neutralized with 10% sodium methoxide in methanol,and then the solvent is evaporated. The residue is triturated withice-water. If a precipitate forms, it is filtered out, rinsed withice-water and dried to provide (2, R=CH₃). If no precipitate forms, thesolution is saturated with sodium chloride and extracted with ethylacetate. Evaporation of the solvent leaves the heterocycle (2, R=CH₃).

Sulfonyl isocyanates (1) are prepared from the correspondingsulfonamides (3) by one of the following two general methods. ##STR33##where J is as previously defined.

The sulfonamide (3) and an alkyl isocyanate (e.g., n-butyl isocyanate)in xylene or other solvent boiling above 135° C. are mixed in thepresence or absence of a catalytic amount of1,4-diaza[2.2.2]bicyclooctane (DABCO) and heated to 135°-140° C. After5-60 minutes phosgene is slowly added to the heated mixture at such arate that the temperature remains between 133° and 135° C. When theconsumption of phosgene has ceased, the mixture is cooled and filteredto remove insoluble material. Finally, the solvent, alkyl isocyanate,and excess phosgene are evaporated, leaving the sulfonyl isocyanate (1).

If desired, the alkyl isocyanate-sulfonamide adduct can be made andisolated before reaction with the phosgene. In this case the sulfonamide(5), alkyl isocyanate, and anhydrous base (e.g., K₂ CO₃) in a polar,aprotic solvent (e.g. acetone, butanone, or acetonitrile) are mixed andheated under reflux for 1 to 6 hours. The reaction mixture is thendiluted with water, and the pH is adjusted to about 3 with acid (e.g.HCl, H₂ SO₄). The adduct is filtered out and dried, and then reactedwith phosgene as described above. This procedure modification isespecially useful when sulfonamide (3) is high melting and has lowsolubility in the phosgenation solvent.

Sulfonyl isocyanates (1) can also be prepared by the following method.##STR34## where J is as previously defined.

The sulfonamide (3) is heated at reflux in an excess of thionylchloride. The reaction is continued until the sulfonamide protons are nolonger detectable in the proton magnetic resonance spectrum. From 16hours to 5 days is typically sufficient for complete conversion to thethionylamide (21) (Equation 18a).

The thionyl chloride is evaporated and the residue is treated with aninert solvent (e.g. toluene) containing at least one equivalent(typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine(typically 0.1 equivalent) is added, and the mixture is heated to about60°-140° C., with 80°-100° preferred. Conversion to the isocyanate (1)is usually substantially complete within 15 minutes to 3 hours (Equation18b). The mixture is then cooled and filtered, and the solvent isevaporated, leaving the sulfonyl isocyanate (1).

The preparation of sulfonamides from ammonia and sulfonyl chlorides iswidely reported in the literature, e.g. Crossley et al., J. Am. Chem.Soc., 60, 2223 (1938).

Certain sulfonyl chlorides are best prepared by chlorosulfonation of asubstituted benzene, naphthalene, or thiophene in tetrachloromethaneaccording to the teachings of H. T. Clarke et al., Org. Synth. Coll.,Vol. 1, 2nd Ed. 1941, p. 85. Other sulfonyl chlorides can be made bydiazotization of the appropriate amine with sodium nitrite inhydrochloric acid, followed by reaction of the diazonium salt withsulfur dioxide and cuprous or cupric chloride in acetic acid accordingto the teachings of H. L. Yale and F. Sowinski, J. Org. Chem., 25, 1824(1960) and of H. Meerwein et al., Chem. Ber., 90, 841 (1957).

Reference to the following patents and applications are suggested forfurther details regarding the preparation of the sulfonamides (3) andsulfonyl isocyanates (1): U.S. Pat. No. 4,169,719; U.S. Pat. No.4,127,405; U.S. Pat. No. 4,394,506; U.S. Pat. No. 4,420,325; U.S. Pat.No. 4,481,029; EP-A-No. 13,480; EP-A-No. 95,925; U.S. Pat. No.4,511,392; U.S. Pat. No. 4,465,505; U.S. Pat. No. 4,460,401; U.S. Pat.No. 4,494,980; U.S. Pat. No. 4,514,211; U.S. Pat. No. 4,586,950; andU.S. Pat. No. 4,589,911.

The following examples further illustrate the synthesis of thisinvention.

EXAMPLE 1 3,5-Dichloro-1-methyl-2(1H)-pyrazinone

Methylaminoacetonitrile hydrochloride (159.78 g, 1.50 mol) was added inone portion to a solution of oxalyl chloride (654.3 mL, 7.50 mol) inanhydrous chlorobenzene (2000 mL). The mixture was heated at 80° C. for8 hours. The solvent was then rotary evaporated, and the residue wastaken up in CH₂ Cl₂ and preabsorbed onto silica gel. Flashchromatography using 6:3:1 dichloromethane-hexanes-ether solvent mixtureas eluant gave a partially purified product that was further purified bychromatography on silica gel using a 8:1:1 dichloromethane-hexane-ethersolvent mixture as eluant. Finally, crystallization from a mixture ofether, 1-chlorobutane; and hexanes furnished the product as a paleyellow, dense crystalline powder melting at 65°-67°. The yield of3,5-dichloro-1-methyl-2(1H)-pyrazinone was 101.60 g.

PMR (CDCl₃, 200 MHz); δ 7.26 (s, 1H, Het-H); 3.60 (s, 3H, N--CH₃). IR(Nujol mull): 1660 (s, C═O) cm⁻¹.

EXAMPLE 2 3-Amino-5-chloro-1-methyl-2(1H)-pyrazinone

A solution of 3,5-dichloro-1-methyl-2(1H)-pyrazinone (7.16 g, 0.040 mol)in dioxane (120 mL) was treated with a concentrated aqueous solution ofammonia (28%, 16 mL, 0.24 mol). After stirring at room temperature forthree days a suspension of solid had formed. The solid was collected,rinsed with a little water, ether, and hexanes and air dried. Theproduct, 3-amino-5-chloro-1-methyl-2(1H)-pyrazinone, was obtained as awhite crystalline powder (4.81 g) melting above 250° C.

PMR (DMSO-d₆, 200 MHz): δ 7.16 (broad s, 2H, NH₂); 6.99 (s, 1H, Het-H);3.34 (s, 3H, N--CH₃).

IR (Nujol mull): 3310 (w, NH); 3170 (w, NH); 1660 (s, C═O) cm⁻¹.

EXAMPLE 3 Methyl2-[[(6-Chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinylamino)carbonylamino]sulfonyl]benzoate

To a mixture of 3-amino-5-chloro-1-methyl-2(1H)-pyrazinone (0.40 g,0.0025 mol) in anhydrous 1,2-dichloroethane (4 mL) under nitrogen wasadded a solution of 2-carbomethoxybenzenesulfonyl isocyanate (0.84 g,0.0035 mol) in anhydrous 1,2-dichloromethane (3 mL). The mixture washeated at reflux for 2 hours. The solvent was rotary evaporated, and theresidue was purified by chromatography on a column of silica gel using asolvent mixture of 1:1 hexanes-acetone containing a little acetic acidas eluant. Rotary evaporation of the appropriate fractions left 0.34 gof methyl2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinylamino)carbonylamino]sulfonyl]benzoateas a crystalline powder melting at 173°-176° C.

PMR (CDCl₃, 200 MHz): δ 11.52 (broad s, 1H, SO₂ NHCO); 8.40 (broad s,2H, C(O)NHHet and aryl H ortho to SO₂); 7.69 (broad s, 3H, other arylH's); 6.96 (s, 1H, Het-H); 3.99 (s, 3H, OCH₃); 3.55 (s, 3H, N--CH₃). IR(Nujol mull): 3240 (w, NH); 1745 (s, C═O); 1705 (s, C═O); 1670 (s, C═O)cm⁻¹.

EXAMPLE 4 Phenyl(6-chloro-3,4-dihydro-4-methyl-3-oxopyrazin-2-yl)carbamate

A mixture of 3-amino-5-chloro-1-methyl-2(1H)-pyrazinone (11.17 g, 0.070mol) in anhydrous N,N-dimethylformamide (90 mL) was treated withoil-free sodium hydride (3.4 g, 0.154 mol). After stirring at roomtemperature for 1 hour, the mixture was cooled with the aid of a dryice-acetone bath while a solution of diphenyl carbonate (16.49 g, 0.077mol) in N,N-dimethylformamide (60 mL) was added as rapidly as possible.A wet ice bath was substituted for the dry ice bath, and the reactionmixture was stirred at approximately 0° C. for 3 hours. The mixture wasallowed to briefly warm to room temperature, and was then poured into astirred mixture of ice (350 g), concentrated hydrochloric acid (42 mL);dichloromethane (318 mL), and tetrahydrofuran (32 mL). The layers wereseparated, and the aqueous layer was extracted with 10:1dichloromethane-tetrahydrofuran (5×100 mL). The combined organicsolutions were dried (Na₂ SO₄), and the solvent was rotary evaporated.After the residue was taken up in toluene, further rotary evaporationleft a tan solid. This solid was taken up in dichloromethane, absorbedonto silica gel and then chromatographed using a 5:1 mixture ofdichloromethane-ether as eluant. Rotary evaporation of the appropriatefractions left 9.70 g of phenyl(6-chloro-3,4-dihydro-4-methyl-3-oxopyrazin-2-yl)carbamate as acrystalline solid melting at 175°-177° C.

PMR (CDCl₃, 200 MHz): δ8.74 (broad s, 1H, NH); 7.20-7.45 (m, 5H, arylH's); 6.96 (s, 1H, Het-H); 3.58 (s, 3H, N--CH₃). IR (Nujol mull): 3320(w, NH); 1770 (s, C═O); 1640 (vs, C═O) cm⁻¹.

EXAMPLE 5N'-[(6-Chloro-3,4-dihydro-4-methyl-3-oxopyrazin-2-yl)aminocarbonyl]-N,N-dimethyl-1,2-benzenedisulfonamide

1,8-Diazabicyclo[5.4.0]undec-7-ene (0.30 mL, 2.00 mmol) was addeddropwise over two minutes to a mixture ofN,N-dimethyl-1,2-benzenedisulfonamide (0.53 g, 2.00 mmol) and phenyl(6-chloro-3,4-dihydro-4-methyl-3-oxopyrazin-2-yl)carbamate (0.56 g, 2.00mmol) in anhydrous acetonitrile (20 mL) under nitrogen. After 3 hours atroom temperature, glacial acetic acid (0.12 mL, 2.10 mmol) was added.The solvent was rotary evaporated and the residue was chromatographed ona column of silica gel using a solvent mixture of 1:1dichloromethane-ether containing 2 mL/L acetic acid as eluant. Theappropriate fractions were evaporated to leave 0.76 g ofN'-[(6-chloro-3,4-dihydro-4-methyl-3-oxopyrazin-2-yl)aminocarbonyl]-N,N-dimethyl-1,2-benzenedisulfonamideas a crystalline solid melting at 227°-230° C.

PMR (CDCl₃, 200 MHz; δ11.90 (slightly broadened s, 1H, SO₂ NHCO); 8.58(m, 1H, Aryl-H ortho to bridge); 8.33 (slightly broadened s, bH,C(O)NH-Het); 8.13 (m, 1H, Aryl-H ortho to SO₂ N(CH₃)₂); 7.78 (m, 2H,other aryl H's); 6.94 (s, 1H, Het-H), 3.55 (s, 3H, NCH₃ on Het); 2.94(s, 6H, N(CH₃)₂). IR (Nujol mull): 1710 (s, C═O); 1670 (s, C═O) cm⁻¹.

Using the procedures and examples shown above, the compounds in Tables1-16 can be prepared.

                                      TABLE 1                                     __________________________________________________________________________     ##STR35##                                                                    R  R.sub.1       R.sub.2                                                                            X      Y      Z  m.p. (°C.)                      __________________________________________________________________________    H  CO.sub.2 CH.sub.3                                                                           H    H      OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Cl     CH 173-176                                H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Br     CH 205-207                                H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.2 CH.sub.3                                                                    Cl     CH 166-168                                H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            H      CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            Br     CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    NH.sub.2                                                                             Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           H    NH.sub.2                                                                             CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    NHCH.sub.3                                                                           Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    N(CH.sub.3).sub.2                                                                    Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Cl     CH                                        CH.sub.3                                                                         CO.sub. 2 CH.sub.3                                                                          H    OCH.sub.3                                                                            Cl     CH                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Cl     CF                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            CF                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Cl     CCl                                       H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                       H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Br     CBr                                       H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Cl     CBr                                       H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                       H  CO.sub.2 CH.sub.3                                                                           H    H      OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Br     N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub. 3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.2 CH.sub.3                                                                    Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            H      N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            Br     N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    H      SCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    (CH.sub.2).sub.2 CH.sub.3                                                            SCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            SCH.sub.2 CH.sub.3                                                                   CH                                        H  CO.sub.2 CH.sub.3                                                                           H    O(CH.sub.2).sub.2 CH.sub.3                                                           SCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                         H  CO.sub.2 CH.sub.3                                                                           H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    NH.sub.2                                                                             Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    NH.sub.2                                                                             CH.sub.3                                                                             N                                         H  CO.sub.2 CH.sub.3                                                                           H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    NHCH.sub.3                                                                           Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                         H  CO.sub.2 CH.sub.3                                                                           H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    N(CH.sub.3).sub.2                                                                    Cl     N                                         H  CO.sub.2 CH.sub.3                                                                           H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                         H  CO.sub.2 CH.sub.3                                                                           H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             Cl     N                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            Cl     N                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           5-F  OCH.sub.3                                                                            Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           3-Cl CH.sub.3                                                                             CH.sub. 3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           5-Br CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           5-CN OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     Cl                                        H  CO.sub.2 CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           5-SCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  CO.sub.2 CH.sub.3                                                                           5-OCF.sub.2 H                                                                      OCH.sub.3                                                                            Cl     CH                                        H  CO.sub.2 CH.sub.3                                                                           6-F  CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             SCH.sub.3                                                                            CH 165-167                                H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             SCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   N                                         H  CO.sub.2 CH.sub.3                                                                           H    CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    (CH.sub.2).sub.2 CH.sub.3                                                            SCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            SCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    OCH.sub.3                                                                            SCH.sub.2 CH.sub.3                                                                   N                                         H  CO.sub.2 CH.sub.3                                                                           H    O(CH.sub.2).sub.2 CH.sub.3                                                           SCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           H    N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           5-Cl CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           6-Br OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             Cl     CH 230-240                                H  CO.sub.2 CH.sub.3                                                                           3-CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.3                                                                           3-F  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  CO.sub.2 CH.sub.3                                                                           6-Cl OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.3                                                                           3-SCH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           5-F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.3                                                                           5-CH.sub.3                                                                         CH.sub.3                                                                             Br     CH                                        H  CO.sub.2 CH.sub.3                                                                           5-SCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                        H  CO.sub.2 CH.sub.3                                                                           5-OCF.sub.2 H                                                                      CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    OCH.sub.3                                                                            Cl     CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             Cl     CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             Br     CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        H  CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H    OCH.sub.3                                                                            Cl     CH                                        H  CO.sub.2 CH.sub.2 CCH                                                                       H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  CO.sub.2 CH(CH.sub.3).sub.2                                                                 H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H    CH.sub.3                                                                             Cl     CH                                        H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                        H  CO.sub.2 (CH.sub.2).sub.2 F                                                                 H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  CO.sub.2 (CH.sub.2).sub.2 Br                                                                H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  CO.sub.2 (CH.sub.2).sub.2 I                                                                 H    CH.sub.3                                                                             Br     CH                                        H  CO.sub.2 CH.sub.2 CF.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                        H  CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        CH.sub.3                                                                         CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    OCH.sub.3                                                                            Cl     CH                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  F             H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  Cl            H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  Br            H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  NO.sub.2      H    CH.sub.3                                                                             Cl     CH                                        H  CH.sub.3      H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  CH.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  (CH.sub.2).sub.2 CH.sub.3                                                                   H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  (CH.sub.2).sub.3 CH.sub.3                                                                   H    OCH.sub.3                                                                            Cl     CH                                        H  CH(CH.sub.3).sub.2                                                                          H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                        H  CF.sub.3      H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  (CH.sub.2).sub.2 F                                                                          H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  (CH.sub.2).sub.2 Br                                                                         H    CH.sub.3                                                                             Br     CH                                        H  CF.sub.2 H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                        H  (CH.sub.2).sub.3 Cl                                                                         H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        H  Cl            H    CH.sub.3                                                                             Cl     CH 208-210                                H  Cl            H    CH.sub.2 CH.sub.3                                                                    Cl     CH 184-187                                H  cyclopropyl   H    OCH.sub.3                                                                            Cl     CH                                        H  cyclobutyl    H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  CHCF.sub.2    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  CClCCl.sub.2  H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  CH.sub.2 CHCHCCl.sub.3                                                                      H    CH.sub.3                                                                             Cl     CH                                        H  CHCHCl        H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  CHCHI         H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  CHCBr.sub.2   H    OCH.sub.2 CH.sub.3                                                                   CH.sub. 3                                                                            CH                                        H  CFCFH         H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  CH.sub.2 CHCF.sub.2                                                                         H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  CHCHCF.sub.3  H    CH.sub.3                                                                             Br     CH                                        H  CFCFCH.sub.3  H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                         H  OCH.sub.3     H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        H  OCH.sub.3     5-CH.sub.3                                                                         OCH.sub.3                                                                            Cl     CH                                        H  OCH.sub.2 CH.sub.3                                                                          H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  O(CH.sub.2).sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  O(CH.sub.2).sub.3 CH.sub.3                                                                  H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  OCH(CH.sub.3).sub.2                                                                         H    CH.sub.3                                                                             Cl     CH                                        H  OCF.sub.2 H   H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  OCF.sub.2 CF.sub.2 H                                                                        H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  O(CH.sub.2).sub.2 CCl.sub.2 H                                                               H    OCH.sub.3                                                                            Cl     CH                                        H  O(CH.sub.2).sub.4 I                                                                         H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  OCH.sub.2 OCH.sub.3                                                                         H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  O(CH.sub.2).sub.2 OCH.sub.3                                                                 H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  O(CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                        H    CH.sub.3                                                                             Cl     CH                                        H  O(CH.sub.2).sub.3 OCH.sub.3                                                                 H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  C(O)N(CH.sub.3).sub.2                                                                       H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  C(O)NHCH.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                            Cl     CH                                        H  C(O)N(CH.sub.3)OCH.sub.3                                                                    H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  C(O)NHOCH.sub.2 CH.sub.3                                                                    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    CH.sub.3                                                                             Cl     CH 227-230                                H  CO.sub.2 CH.sub.3                                                                           5-Cl CH.sub.3                                                                             Cl     CH 227-230                                H  SO.sub.2 NHcyclopropyl                                                                      H    OCH.sub.3                                                                            Cl     CH                                        CH.sub.3                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  SO.sub.2 N(CH.sub.3).sub.2                                                                  3-CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H    CH.sub.3                                                                             Cl     CH                                        H  SO.sub.2 NH.sub.2                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  C(O)N(CH.sub.3).sub.2                                                                       5-OCH.sub.3                                                                        CH.sub.3                                                                             Cl     CH 190-195                                H  SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               H    CH.sub. 3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                         H  SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                        H  SCH.sub.3     H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  SCH.sub.2 CHCH.sub.3                                                                        H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  SCH.sub.2 CCH.sub.3                                                                         H    CH.sub.3                                                                             Br     CH                                        H  S(CH.sub.2).sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                        H  S(O)CH.sub.3  H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        H  SCF.sub.2 H   H    OCH.sub.3                                                                            Cl     CH                                        H  SCF.sub.2 CF.sub.2 H                                                                        H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  S(CH.sub.2).sub.2 Cl                                                                        H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  S(CH.sub.2).sub.2 I                                                                         H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  S(CH.sub.2).sub.3 Br                                                                        H    CH.sub.3                                                                             Cl     CH                                        H  S(O)CF.sub.2 CF.sub.2 H                                                                     H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  S(O)(CH.sub.2).sub.2 I                                                                      H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  S(O).sub.2 CH.sub.3                                                                         H    OCH.sub.3                                                                            Cl     CH                                        H  S(O).sub.2 CH.sub.2 CH.sub.3                                                                H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  S(O).sub.2 CH.sub.2 CCH                                                                     H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  S(O).sub.2 CF.sub.2 H                                                                       H    CH.sub.3                                                                             Cl     CH                                        H  S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  S(O).sub.2 (CH.sub.2).sub.2 I                                                               H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  C(O)CH.sub.3  H    OCH.sub.3                                                                            Cl     CH                                        H  C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  C(O)CH.sub.2 CH.sub.3                                                                       H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  C(O)cyclo-C.sub.3 H.sub.5                                                                   H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  C(O)cyclo-C.sub.4 H.sub.7                                                                   H    CH.sub.3                                                                             Cl     CH                                        H  S(O).sub.2 CH.sub.3                                                                         H    CH.sub.3                                                                             Cl     CH 230-240                                H  C(O)cyclo-C.sub.5 H.sub.9                                                                   H    OCH.sub.3                                                                            Cl     CH                                        H  C(O)cyclo-C.sub.3 F.sub.5                                                                   H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  C(O)CF.sub.3  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  C(O)(CH.sub.2).sub.4 F                                                                      H    CH.sub.3                                                                             Cl     CH                                        H  C(O) cyclo-(CHCH.sub.2 CCl.sub.2)                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  CH.sub.2 CN   H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  L-1, R.sub.h = H                                                                            H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                        H  L-1, R.sub.h = CH.sub.3                                                                     H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  L-2, R.sub.h = H                                                                            H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  L-2, R.sub.h = CH.sub.3                                                                     H    CH.sub.3                                                                             Br     CH                                        H  L-3           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                        H  L-4           H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        H  L-5           H    OCH.sub.3                                                                            Cl     CH                                        H  L-6           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  L-7           H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  L-8           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  L-9           H    CH.sub.3                                                                             Cl     CH                                        H  L-10          H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  L-11          H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  L-12          H    OCH.sub.3                                                                            Cl     CH                                        H  L-13          H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  L-14          H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  L-15          H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  L-16, R.sub.i = H                                                                           H    CH.sub.3                                                                             Cl     CH                                        H  L-16, R.sub.i = CH.sub.3                                                                    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  L-17          H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  L-18          H    OCH.sub.3                                                                            Cl     CH                                        H  L-19          H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  L-20          H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  L-21          H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  L-22          H    CH.sub.3                                                                             Cl     CH                                        H  L-23          H    OCH.sub.3                                                                            Cl     CH                                        H  L-24          H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  L-25          H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  L-26, R.sub.j = H                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  L-26, R.sub.j = CH.sub.3                                                                    H    CH.sub.3                                                                             Cl     CH                                        H  L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  L-27, R.sub.j = H                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  L-27, R.sub.j = CH.sub.3                                                                    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                        H  L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                        H  L-28, R.sub.k = H                                                                           H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                        H  L-28, R.sub.k = CH.sub.3                                                                    H    CH.sub.3                                                                             Br     CH                                        H  L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                        H  L-28, R.sub.k = OCH.sub.3                                                                   H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                        H  L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          H    OCH.sub.3                                                                            Cl     CH                                        H  L-28, R.sub.k = SCH.sub.3                                                                   H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  L-29, R.sub.k = H                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  L-29, R.sub.k = CH.sub.3                                                                    H    CH.sub.3                                                                             Cl     CH                                        H  L-29, R.sub.k = CH.sub.2 CH.sub.3                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  L-29, R.sub.k = OCH.sub.3                                                                   H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          H    OCH.sub.3                                                                            Cl     CH                                        H  L-29, R.sub.k = SCH.sub.3                                                                   H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  L-29, R.sub.k = SCH.sub. 2 CH.sub.3                                                         H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  L-30, R.sub.m = H                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  L-30, R.sub.m = CH.sub.3                                                                    H    CH.sub.3                                                                             Cl     CH                                        H  L-30, R.sub.m = CH.sub.2 CH.sub.3                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                         H  L-31, R.sub.m = H                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                         H  L-31, R.sub.m = CH.sub.3                                                                    H    OCH.sub.3                                                                            Cl     CH                                        H  L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                        H  L-32, R.sub.m = H                                                                           H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        H  L-32, R.sub.m = CH.sub.3                                                                    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                        H  L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           H    CH.sub.3                                                                             Cl     CH                                        H  L-33, R.sub.n = H                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             N                                         H  L-33, R.sub.n = CH.sub.3                                                                    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                        __________________________________________________________________________

                                      TABLE 2                                     __________________________________________________________________________     ##STR36##                                                                    R    R.sub.3  R.sub.2                                                                              X        Y        Z    m.p. (°C.)                 __________________________________________________________________________    H    CO.sub.2 CH.sub.3                                                                      H      H        OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Br       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.2 CH.sub.3                                                                     CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 O(CH.sub.2).sub.2 CH.sub.3                                                             CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 CH.sub.3 CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 CH.sub.2 CH.sub.3                                                                      CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 (CH.sub.2).sub.2 CH.sub. 3                                                             CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.2 CH.sub.3                                                                      Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      (CH.sub.2).sub.2 CH.sub.3                                                              Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      (CH.sub.2).sub.2 CH.sub.3                                                              OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              H        CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              CH.sub.3 CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                      CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              (CH.sub.2).sub.2 CH.sub.3                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                     CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              O(CH.sub.2).sub.2 CH.sub.3                                                             CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 O(CH.sub.2).sub.2 CH.sub.3                                                             CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              SCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 SCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 SCH.sub.2 CH.sub.3                                                                     CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 SCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              Br       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.2 CH.sub.3                                                                     Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.2 CH.sub.3                                                                     CH.sub.3 CH                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      O(CH.sub.2).sub.2 CH.sub.3                                                             Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      O(CH.sub.2).sub.2 CH.sub.3                                                             CH.sub.3 CH                                     H    CO.sub.2 CH.sub.3                                                                      H      O(CH.sub.2).sub.2 CH.sub.3                                                             OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      NH.sub.2 Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      NH.sub.2 CH.sub.3 CH                                     H    CO.sub.2 CH.sub.3                                                                      H      NH.sub.2 OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      NHCH.sub.3                                                                             Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      NHCH.sub.3                                                                             CH.sub.3 CH                                     H    CO.sub.2 CH.sub.3                                                                      H      NHCH.sub.3                                                                             OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      N(CH.sub.3).sub.2                                                                      Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      H      N(CH.sub.3).sub.2                                                                      CH.sub.3 CH                                     H    CO.sub.2 CH.sub. 3                                                                     H      N(CH.sub.3).sub.2                                                                      OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      NHCH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                     CH                                     CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Cl       CH                                     CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              Cl       CH                                     CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.3                                                                              CH                                     CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              CH.sub.3 CH                                     CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Cl       CF                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.3                                                                              CF                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              OCH.sub.3                                                                              CF                                     H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              CH.sub.3 CF                                     H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Cl       CCl                                    H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.3                                                                              CCl                                    H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Br       CBr                                    H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Cl       CBr                                    H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.3                                                                              CBr                                    H    CO.sub.2 CH.sub.3                                                                      H      H        OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Br       N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.2 CH.sub.3                                                                     N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 O(CH.sub.2).sub.2 CH.sub.3                                                             N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 CH.sub.3 N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 CH.sub.2 CH.sub.3                                                                      N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 (CH.sub.2).sub.2 CH.sub.3                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.2 CH.sub.3                                                                      Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      CH.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      (CH.sub.2).sub.2 CH.sub.3                                                              Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      (CH.sub.2).sub.2 CH.sub.3                                                              OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              H        N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              CH.sub.3 N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                      N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              (CH.sub.2).sub.2 CH.sub.3                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                     N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              O(CH.sub.2).sub.2 CH.sub.3                                                             N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              Br       N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.2 CH.sub.3                                                                     Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.2 CH.sub.3                                                                     CH.sub.3 N                                      H    CO.sub.2 CH.sub.3                                                                      H      OCH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      O(CH.sub.2).sub.2 CH.sub.3                                                             Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      O(CH.sub.2).sub.2 CH.sub.3                                                             CH.sub.3 N                                      H    CO.sub.2 CH.sub.3                                                                      H      O(CH.sub.2).sub.2 CH.sub.3                                                             OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      NH.sub.2 Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      NH.sub.2 CH.sub.3 N                                      H    CO.sub.2 CH.sub.3                                                                      H      NH.sub.2 OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      NHCH.sub.3                                                                             Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      NHCH.sub.3                                                                             CH.sub.3 N                                      H    CO.sub.2 CH.sub.3                                                                      H      NHCH.sub.3                                                                             OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      N(CH.sub.3).sub. 2                                                                     Cl       N                                      H    CO.sub.2 CH.sub.3                                                                      H      N(CH.sub.3).sub.2                                                                      CH.sub.3 N                                      H    CO.sub.2 CH.sub.3                                                                      H      N(CH.sub.3).sub.2                                                                      OCH.sub.3                                                                              N                                      H    CO.sub.2 CH.sub.3                                                                      H      NHCH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                     N                                      CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Cl       N                                      CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              Cl       N                                      CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      CH.sub.3 OCH.sub.3                                                                              N                                      CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      CH.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                              N                                      CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              CH.sub.3 N                                      CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                      H      OCH.sub.3                                                                              OCH.sub.3                                                                              N                                      H    Cl       H      OCH.sub.3                                                                              Cl       CH                                     H    NO.sub.2 H      CH.sub.3 CH.sub.3 CH                                     H    CO.sub.2 CH.sub.2 CH.sub.3                                                             H      CH.sub.3 OCH.sub.3                                                                              CH                                     H    SO.sub.2 N(CH.sub.3).sub.2                                                             H      OCH.sub.3                                                                              CH.sub.3 CH                                     H    SO.sub.2 CH.sub.3                                                                      H      CH.sub.3 Cl       CH                                     H    SO.sub.2 CH.sub.2 CH.sub.3                                                             H      CH.sub.3 OCH.sub.3                                                                              N                                      H    OCH.sub.3                                                                              H      CH.sub.3 OCH.sub.2 CH.sub.3                                                                     N                                      H    OCH.sub.2 CH.sub.3                                                                     H      OCH.sub.2 CH.sub.3                                                                     CH.sub.3 CH                                     H    CO.sub.2 CH.sub.3                                                                      3-F    OCH.sub.3                                                                              OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      5-Br   CH.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                              CH                                     H    CO.sub.2 CH.sub.3                                                                      5-CN   CH.sub.3 Br       CH                                     H    CO.sub.2 CH.sub.3                                                                      6-CH.sub.3                                                                           CH.sub.3 OCH.sub.2 CH.sub.3                                                                     CH                                     H    CO.sub.2 CH.sub.3                                                                      5-OCH.sub.3                                                                          CH.sub.3 CH.sub.3 CH.sub.2                                                                      CH                                     H    CO.sub.2 CH.sub.3                                                                      5-SCH.sub.3                                                                          OCH.sub.3                                                                              Cl       CH                                     H    CO.sub.2 CH.sub.3                                                                      5-OCF.sub.2 H                                                                        CH.sub.3 CH.sub.3 CH                                     __________________________________________________________________________

                                      TABLE 3                                     __________________________________________________________________________     ##STR37##                                                                    R  R.sub.4       X      Y      Z  m.p. (°C.)                           __________________________________________________________________________    H  CO.sub.2 CH.sub.3                                                                           H      OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     CH 230-233 (d)                                 H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Br     CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    OCH.sub. 3                                                                           CH                                             H  CO.sub.2 CH.sub.3                                                                           (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            H      CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                             H  CO.sub.2 CH.sub.3                                                                           H      SCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             SCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             SCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            Br     CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           NH.sub.2                                                                             Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           NH.sub.2                                                                             CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           NH.sub.2                                                                             OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           NHCH.sub.3                                                                           Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                             CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     CH                                             CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            Cl     CH                                             CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     CF                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CF                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             CF                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     CCl                                            H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                            H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Br     CBr                                            H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     CBr                                            H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                            H  CO.sub.2 CH.sub.3                                                                           H      OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Br     N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                             N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                              H  CO.sub.2 CH.sub. 3                                                                          CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            H      N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            Br     N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           O(CH.sub. 2).sub.2 CH.sub.3                                                          Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                              H  CO.sub.2 CH.sub.3                                                                           O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           NH.sub.2                                                                             Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           NH.sub.2                                                                             CH.sub.3                                                                             N                                              H  CO.sub.2 CH.sub.3                                                                           NH.sub.2                                                                             OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           NHCH.sub.3                                                                           Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           NHCH.sub.3                                                                           CH.sub.3                                                                             N                                              H  CO.sub.2 CH.sub.3                                                                           NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    Cl     N                                              H  CO.sub.2 CH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                              H  CO.sub.2 CH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                              CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     N                                              CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            Cl     N                                              CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                              CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                              CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             N                                              CH.sub.3                                                                         CO.sub.2 CH.sub. 3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     Cl                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Cl     CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             Br     CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                             H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                            Cl     CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             Cl     CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             Br     CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                             H  CO.sub.2 CH.sub.2 CHCH.sub.3                                                                OCH.sub.3                                                                            Cl     CH                                             H  CO.sub.2 CH.sub.2 CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  CO.sub.2 CH(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         CH.sub.3                                                                             Cl     CH                                             H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  CO.sub.2 CH.sub.2 OCH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  CO.sub.2 (CH.sub.2).sub.2 Cl                                                                OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                             H  CO.sub.2 (CH.sub.2).sub.2 F                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  CO.sub.2 (CH.sub.2).sub.2 Br                                                                CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                             H  CO.sub.2 (CH.sub.2).sub.2 I                                                                 CH.sub.3                                                                             Br     CH                                             H  CO.sub.2 CH.sub.2 CF.sub.3                                                                  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                             H  CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                             CH.sub.3                                                                         CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                            Cl     CH                                             H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  F             OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  Cl            CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  Br            CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  NO.sub.2      CH.sub.3                                                                             Cl     CH                                             H  CH.sub.3      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  CH.sub.2 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  (CH.sub.2).sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  CH(CH.sub.3).sub.2                                                                          OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                             H  CF.sub.3      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  (CH.sub.2).sub.2 F                                                                          CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                             H  (CH.sub.2).sub.2 Br                                                                         CH.sub.3                                                                             Br     CH                                             H  CF.sub.2 H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                             H  CHCF.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  CClCCl.sub.2  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  CH.sub.2 CHCHCCl.sub.3                                                                      CH.sub.3                                                                             Cl     CH                                             H  CHCHCl        CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  CHCHI         CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  CHCBr.sub.2   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                             H  CFCFH         OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  CH.sub.2 CHCF.sub.2                                                                         CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                             H  CHCHCF.sub.3  CH.sub.3                                                                             Br     CH                                             H  CF CFCH.sub.3 CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                              H  OCH.sub.3     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                             H  OCH.sub.3     OCH.sub.3                                                                            Cl     CH                                             H  OCH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  C(O)N(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  C(O)NHCH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            Cl     CH                                             H  C(O)N(CH.sub.3)OCH.sub.3                                                                    CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  C(O)NHOCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                             Cl     CH                                             H  SO.sub.2 NHcyclopropyl                                                                      OCH.sub.3                                                                            Cl     CH                                             CH.sub.3                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 CH.sub.3                                                                             Cl     CH                                             H  SO.sub.2 NH.sub.2                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      OCH.sub.2 CH.sub. 3                                                                  CH.sub.3                                                                             CH                                             H  SCH.sub.3     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  SCH.sub.2 CHCH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                             H  SCH.sub.2 CCH.sub.3                                                                         CH.sub.3                                                                             Br     CH                                             H  S(CH.sub.2).sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                             H  S(O)CH.sub.3  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                             H  SCF.sub.2 H   OCH.sub.3                                                                            Cl     CH                                             H  SCF.sub.2 CF.sub.2 H                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  S(CH.sub.2).sub.2 Cl                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  S(CH.sub.2).sub.2 I                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  S(CH.sub.2).sub.3 Br                                                                        CH.sub.3                                                                             Cl     CH                                             H  S(O)CF.sub.2 CF.sub.2 H                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  S(O)(CH.sub.2).sub.2 I                                                                      CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  S(O).sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            Cl     CH                                             H  S(O).sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  S(O).sub.2 CH.sub.2 CCH                                                                     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  S(O).sub. 2 CF.sub.2 H                                                                      CH.sub.3                                                                             Cl     CH                                             H  S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  S(O).sub.2 (CH.sub.2).sub.2 I                                                               CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  C(O)CH.sub.3  OCH.sub.3                                                                            Cl     CH                                             H  C(O)(CH.sub.2).sub.3 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  C(O)CH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  C(O)cyclo-C.sub.3 H.sub.5                                                                   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  C(O)cyclo-C.sub.4 H.sub.7                                                                   CH.sub.3                                                                             Cl     CH                                             H  C(O)cyclo-C.sub.5 H.sub.9                                                                   OCH.sub.3                                                                            Cl     CH                                             H  C(O)cyclo-C.sub.3 F.sub.5                                                                   CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  C(O)CF.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  C(O)(CH.sub.2).sub.4 F                                                                      CH.sub.3                                                                             Cl     CH                                             H  C(O)cyclo-(CHCH.sub.2 CCl.sub.2)                                                            CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  L-1, R.sub.h = H                                                                            OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                             H  L-1, R.sub.h = CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  L-2, R.sub.h = H                                                                            CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                             H  L-2, R.sub.h =  CH.sub.3                                                                    CH.sub.3                                                                             Br     CH                                             H  L-3           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                             H  L-4           CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                             H  L-5           OCH.sub.3                                                                            Cl     CH                                             H  L-6           CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  L-7           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  L-8           OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  L-9           CH.sub.3                                                                             Cl     CH                                             H  L-10          CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  L-11          CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  L-12          OCH.sub.3                                                                            Cl     CH                                             H  L-13          CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  L-14          CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  L-15          OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  L-16, R.sub.i = H                                                                           CH.sub.3                                                                             Cl     CH                                             H  L-16, R.sub.i = CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  L-17          CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  L-18          OCH.sub.3                                                                            Cl     CH                                             H  L-19          CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  L-20          CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  L-21          OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  L-22          CH.sub.3                                                                             Cl     CH                                             H  L-23          OCH.sub.3                                                                            Cl     CH                                             H  L-24          CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  L-25          CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  L-26, R.sub.j = H                                                                           OCH.sub.3                                                                            CH.sub. 3                                                                            CH                                             H  L-26, R.sub.j = CH.sub.3                                                                    CH.sub.3                                                                             Cl     CH                                             H  L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  L-27, R.sub.j = H                                                                           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  L-27, R.sub.j = CH.sub.3                                                                    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                             H  L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                             H  L-28, R.sub.k = H                                                                           CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                             H  L-28, R.sub.k = CH.sub.3                                                                    CH.sub.3                                                                             Br     CH                                             H  L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                             H  L-28, R.sub.k = OCH.sub.3                                                                   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                             H  L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                            Cl     CH                                             H  L-28, R.sub.k = SCH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  L-29, R.sub.k = H                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  L-29, R.sub.k = CH.sub.3                                                                    CH.sub.3                                                                             Cl     CH                                             H  L-29, R.sub.k = CH.sub.2 CH.sub.3                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  L-29, R.sub.k = OCH.sub.3                                                                   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                            Cl     CH                                             H  L-29, R.sub.k = SCH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  L-29, R.sub.k = SCH.sub.2 CH.sub.3                                                          CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  L-30, R.sub.m = H                                                                           OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  L-30, R.sub.m = CH.sub.3                                                                    CH.sub.3                                                                             Cl     CH                                             H  L-30, R.sub.m = CH.sub.2 CH.sub.3                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                              H  L-31, R.sub.m = H                                                                           CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                              H  L-31, R.sub.m = CH.sub.3                                                                    OCH.sub.3                                                                            Cl     CH                                             H  L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH.sub.3                                                                             CH                                             H  L-32, R.sub.m = H                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             H  L-32, R.sub.m = CH.sub.3                                                                    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                             H  L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           CH.sub.3                                                                             Cl     CH                                             H  L-33, R.sub.n = H                                                                           CH.sub.3                                                                             CH.sub.3                                                                             N                                              H  L-33, R.sub.n = CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                             __________________________________________________________________________

                                      TABLE 4                                     __________________________________________________________________________     ##STR38##                                                                    R  R.sub.4       R.sub.5                                                                           X      Y      Z  m.p. (°C.)                       __________________________________________________________________________    H  CO.sub.2 CH.sub.3                                                                           H   H      OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Br     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            H      CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             SCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             SCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           SCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub. 2 CH.sub.3                                                                   SCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Br     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CF                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CF                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CF                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CCl                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Br     CBr                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CBr                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                        H  CO.sub.2 CH.sub.3                                                                           H   H      OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     N                                          H  CO.sub.2 CH.sub. 3                                                                          H   CH.sub.3                                                                             Br     N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            H      N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  CO.sub. 2 CH.sub.3                                                                          H   OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Br     N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3 ).sub.2                                                                   Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Cl     N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           F   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           Cl  CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           Br  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             Cl     Cl                                         H  CO.sub.2 CH.sub.3                                                                           F   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           Cl  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           Br  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           F   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 CH.sub.3                                                                           Cl  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           F   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             Br     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             Cl     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             Br     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.2 CCH                                                                       H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH(CH.sub.3).sub.2                                                                 H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H   CH.sub.3                                                                             Cl     CH                                         H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CO.sub.2 (CH.sub.2).sub.2 F                                                                 H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 (CH.sub.2).sub.2 Br                                                                H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 (CH.sub.2).sub.2 I                                                                 H   CH.sub.3                                                                             Br     CH                                         H  CO.sub.2 CH.sub.2 CF.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  F             H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  Cl            H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  Br            H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  NO.sub.2      H   CH.sub.3                                                                             Cl     CH                                         H  CH.sub.3      H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CH.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  (CH.sub.2).sub.2 CH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CH(CH.sub.3).sub.2                                                                          H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CF.sub.3      H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  (CH.sub.2).sub.2 F                                                                          H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  (CH.sub.2).sub.2 Br                                                                         H   CH.sub.3                                                                             Br     CH                                         H  CF.sub.2 H    H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  CHCF.sub.2    H   CH.sub. 3                                                                            OCH.sub.3                                                                            CH                                         H  CClCCl.sub.2  H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CH.sub.2 CHCHCCl.sub.2                                                                      H   CH.sub.3                                                                             Cl     CH                                         H  CHCHCl        H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CHCHI         H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CHCBr.sub.2   H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CFCFH         H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CH.sub.2 CHCF.sub.2                                                                         H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CHCHCF.sub.3  H   CH.sub.3                                                                             Br     CH                                         H  CFCFCH.sub.3  H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                          H  OCH.sub.3     H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  OCH.sub.3     Cl  OCH.sub.3                                                                            Cl     CH                                         H  OCH.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)N(CH.sub.3).sub.2                                                                       H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  C(O)NHCH.sub.2 CH.sub.3                                                                     H   OCH.sub.3                                                                            Cl     CH                                         H  C(O)N(CH.sub.3)OCH.sub.3                                                                    H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)NHOCH.sub.2 CH.sub.3                                                                    H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO.sub.2 N(CH.sub.3).sub.2                                                                  H   CH.sub.3                                                                             Cl     CH                                         H  SO.sub.2 NHcyclopropyl                                                                      H   OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                  H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H   CH.sub.3                                                                             Cl     CH                                         H  SO.sub.2 NH.sub.2                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  SCH.sub.3     H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  SCH.sub.2 CHCH.sub.3                                                                        H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  SCH.sub.2 CCH.sub.3                                                                         H   CH.sub.2                                                                             Br     CH                                         H  S(CH.sub.2).sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  S(O)CH.sub.3  H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  SCF.sub.2 H   H   OCH.sub.3                                                                            Cl     CH                                         H  SCF.sub.2 CF.sub.2 H                                                                        H   CH.sub. 3                                                                            CH.sub.3                                                                             CH                                         H  S(CH.sub.2).sub.2 Cl                                                                        H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  S(CH.sub.2).sub.2 I                                                                         H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  S(CH.sub.2).sub.3 Br                                                                        H   CH.sub.3                                                                             Cl     CH                                         H  S(O)CF.sub.2 CF.sub.2 H                                                                     H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  S(O)(CH.sub.2).sub.2 I                                                                      H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  S(O).sub.2 CH.sub.3                                                                         H   OCH.sub.3                                                                            Cl     CH                                         H  S(O).sub.2 CH.sub.2 CH.sub.3                                                                H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  S(O).sub.2 CH.sub.2 CCH                                                                     H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  S(O).sub.2 CF.sub.2 H                                                                       H   CH.sub.3                                                                             Cl     CH                                         H  S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  S(O).sub.2 (CH.sub.2).sub.2 I                                                               H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  C(O)CH.sub.3  H   OCH.sub.3                                                                            Cl     CH                                         H  C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)CH.sub.2 CH.sub.3                                                                       H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)cyclo-C.sub. 3 H.sub.5                                                                  H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  C(O)cyclo-C.sub.4 H.sub.7                                                                   H   CH.sub.3                                                                             Cl     CH                                         H  C(O)cyclo-C.sub.5 H.sub.9                                                                   H   OCH.sub.3                                                                            Cl     CH                                         H  C(O)cyclo-C.sub.3 F.sub.5                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)CF.sub.3  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  C(O)(CH.sub.2).sub.4 F                                                                      H   CH.sub.3                                                                             Cl     CH                                         H  C(O)cyclo-(CHCH.sub.2 CCl.sub.2)                                                            H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-1, R.sub.h = H                                                                            H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  L-1, R.sub.h = CH.sub.3                                                                     H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  L-2, R.sub.h = H                                                                            H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  L-2, R.sub.h = CH.sub.3                                                                     H   CH.sub.3                                                                             Br     CH                                         H  L-3           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  L-4           H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  L-5           H   OCH.sub.3                                                                            Cl     CH                                         H  L-6           H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-7           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-8           H   OCH.sub.3                                                                            CH.sub. 3                                                                            CH                                         H  L-9           H   CH.sub.3                                                                             Cl     CH                                         H  L-10          H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-11          H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-12          H   OCH.sub.3                                                                            Cl     CH                                         H  L-13          H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-14          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-15          H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-16, R.sub.i = H                                                                           H   CH.sub.3                                                                             Cl     CH                                         H  L-16, R.sub.i = CH.sub.3                                                                    H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-17          H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-18          H   OCH.sub.3                                                                            Cl     CH                                         H  L-19          H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-20          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-21          H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-22          H   CH.sub.3                                                                             Cl     CH                                         H  L-23          H   OCH.sub.3                                                                            Cl     CH                                         H  L-24          H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-25          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-26, R.sub.j = H                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-26, R.sub.j = CH.sub.3                                                                    H   CH.sub.3                                                                             Cl     CH                                         H  L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             OCH.sub. 3                                                                           N                                          H  L-27, R.sub.j = H                                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-27, R.sub.j = CH.sub.3                                                                    H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  L-28, R.sub.k = H                                                                           H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  L-28, R.sub.k = CH.sub.3                                                                    H   CH.sub.3                                                                             Br     CH                                         H  L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  L-28, R.sub.k = OCH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          H   OCH.sub.3                                                                            Cl     CH                                         H  L-28, R.sub.k = SCH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-29, R.sub.k = H                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-29, R.sub.k = CH.sub.3                                                                    H   CH.sub.3                                                                             Cl     CH                                         H  L-29, R.sub.k =  CH.sub.2 CH.sub.3                                                          H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-29, R.sub.k = OCH.sub.3                                                                   H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          H   OCH.sub.3                                                                            Cl     CH                                         H  L-29, R.sub.k = SCH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-29, R.sub.k = SCH.sub.2 CH.sub.3                                                          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-30, R.sub.m = H                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-30, R.sub.m = CH.sub.3                                                                    H   CH.sub.3                                                                             Cl     CH                                         H  L-30, R.sub.m = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-31, R.sub.m = H                                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-31, R.sub.m = CH.sub.3                                                                    H   OCH.sub.3                                                                            Cl     CH                                         H  L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-32, R.sub.m = H                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-32, R.sub.m = CH.sub.3                                                                    H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             Cl     CH                                         H  L-33, R.sub.n = H                                                                           H   CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  L-33, R.sub.n = CH.sub.3                                                                    H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         __________________________________________________________________________

                                      TABLE 5                                     __________________________________________________________________________     ##STR39##                                                                    R  R.sub.4       R.sub.5                                                                          X      Y      Z  m.p. (°C.)                        __________________________________________________________________________    H  CO.sub.2 CH.sub.3                                                                           H  H      OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Br     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.2 CH.sub.3                                                                    Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            H      CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             SCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  H      SCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             SCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            SCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  NH.sub.2                                                                             SCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            Br     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.2 CH.sub.3                                                                   Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           H  O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  NH.sub.2                                                                             Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  NH.sub.2                                                                             CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           H  NH.sub.2                                                                             OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  NHCH.sub.3                                                                           Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           H  NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  N(CH.sub.3).sub.2                                                                    Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           H  N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           H  N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Cl     CH                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            Cl     CH                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Cl     CF                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            CF                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                          H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            CH.sub.3                                                                             CF                                          H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Cl     CCl                                         H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                         H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Br     CBr                                         H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Cl     CBr                                         H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                         H  CO.sub.2 CH.sub.3                                                                           H  H      OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Br     N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             CH.sub.3                                                                             N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.2 CH.sub.3                                                                    Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            H      N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            Br     N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.2 CH.sub.3                                                                   Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                           H  CO.sub.2 CH.sub.3                                                                           H  OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                           H  CO.sub.2 CH.sub.3                                                                           H  O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  NH.sub.2                                                                             Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  NH.sub.2                                                                             CH.sub.3                                                                             N                                           H  CO.sub.2 CH.sub.3                                                                           H  NH.sub.2                                                                             OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  NHCH.sub.3                                                                           Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  NHCH.sub.3                                                                           CH.sub.3                                                                             N                                           H  CO.sub.2 CH.sub.3                                                                           H  NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  N(CH.sub.3).sub.2                                                                    Cl     N                                           H  CO.sub.2 CH.sub.3                                                                           H  N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                           H  CO.sub.2 CH.sub.3                                                                           H  N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           H  NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                           CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             Cl     N                                           CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            Cl     N                                           CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                           CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            CH.sub.3                                                                             N                                           CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           F  OCH.sub.3                                                                            Cl     CH                                          H  CO.sub.2 CH.sub.3                                                                           Cl CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           Br CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                         CH.sub.3                                                                             Cl     Cl                                          H  CO.sub.2 CH.sub.3                                                                           F  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           Cl CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           Br OCH.sub. 3                                                                           CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.3                                                                           F  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  CO.sub.2 CH.sub.3                                                                           Cl OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.3                                                                           F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                         CH.sub.3                                                                             Br     CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                            Cl     CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             Cl     CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  CO.sub. 2 CH.sub.2 CH.sub.3                                                                 H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             Br     CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                          H  CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H  OCH.sub.3                                                                            Cl     CH                                          H  CO.sub.2 CH.sub.2 CCH                                                                       H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  CO.sub.2 CH(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H  CH.sub.3                                                                             Cl     CH                                          H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  CO.sub.2 (CH.sub.3).sub.2 F                                                                 H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  CO.sub.2 (CH.sub.2).sub. 2 Br                                                               H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  CO.sub.2 (CH.sub.2).sub.2 I                                                                 H  CH.sub.3                                                                             Br     CH                                          H  CO.sub.2 CH.sub.2 CF.sub.3                                                                  H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                          H  CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                          CH.sub.3                                                                         CO.sub.2 CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                            Cl     CH                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  F             H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  Cl            H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  Br            H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  NO.sub.2      H  CH.sub.3                                                                             Cl     CH                                          H  CH.sub.3      H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  CH.sub.2 CH.sub.3                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  (CH.sub.2).sub.2 CH.sub.3                                                                   H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  CH(CH.sub.3).sub.2                                                                          H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  CF.sub.3      H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  (CH.sub.2).sub.2 F                                                                          H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  (CH.sub.2).sub.2 Br                                                                         H  CH.sub.3                                                                             Br     CH                                          H  CF.sub.2 H    H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                          H  CHCF.sub.2    H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  CClCCl.sub.2  H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  CH.sub.2 CHCHCCl.sub.3                                                                      H  CH.sub.3                                                                             Cl     CH                                          H  CHCHCl        H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  CHCHI         H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  CHCBr.sub.2   H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  CFCFH         H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  CH.sub.2 CHCF.sub.2                                                                         H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  CHCHCF.sub.3  H  CH.sub.3                                                                             Br     CH                                          H  CFCFCH.sub.3  H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                           H  OCH.sub.3     H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                          H  OCH.sub.3     Cl OCH.sub.3                                                                            Cl     CH                                          H  OCH.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  C(O)N(CH.sub.3).sub.2                                                                       H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  C(O)NHCH.sub.2 CH.sub.3                                                                     H  OCH.sub.3                                                                            Cl     CH                                          H  C(O)N(CH.sub.3)OCH.sub.3                                                                    H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  C(O)NHOCH.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H  OCH.sub.3                                                                            CH.sub. 3                                                                            CH                                          H  SO.sub.2 N(CH.sub.3).sub.2                                                                  H  CH.sub.3                                                                             Cl     CH 195-198                                  H  C(O)N(CH.sub.3).sub.2                                                                       H  CH.sub.3                                                                             Cl     CH 200-210 (d)                              H  SO.sub.2 NHcyclopropyl                                                                      H  OCH.sub.3                                                                            Cl     CH                                          CH.sub.3                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                  H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H  CH.sub.3                                                                             Cl     CH                                          H  SO.sub.2 NH.sub.2                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  SCH.sub.3     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  SCH.sub.2 CHCH.sub.3                                                                        H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  SCH.sub.2 CCH.sub.3                                                                         H  CH.sub.3                                                                             Br     CH                                          H  S(CH.sub.2).sub.2 CH.sub.3                                                                  H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                          H  S(O)CH.sub.3  H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                          H  SCF.sub.2 H   H  OCH.sub.3                                                                            Cl     CH                                          H  SCF.sub.2 CF.sub.2 H                                                                        H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  S(CH.sub.2).sub.2 Cl                                                                        H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  S(CH.sub.2).sub.2 I                                                                         H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  S(CH.sub.2).sub.3 Br                                                                        H  CH.sub.3                                                                             Cl     CH                                          H  S(O)CF.sub.2 CF.sub.2 H                                                                     H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  S(O)(CH.sub.2).sub.2 I                                                                      H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  S(O).sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                            Cl     CH                                          H  S(O).sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  S(O).sub.2 CH.sub.2 CCH                                                                     H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  S(O).sub.2 CF.sub.2 H                                                                       H  CH.sub.3                                                                             Cl     CH                                          H  S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  S(O).sub.2 (CH.sub.2).sub.2 I                                                               H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  C(O)CH.sub.3  H  OCH.sub.3                                                                            Cl     CH                                          H  C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  C(O)CH.sub.2 CH.sub.3                                                                       H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  C(O)cyclo-C.sub.3 H.sub.5                                                                   H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  C(O)cyclo-C.sub.4 H.sub.7                                                                   H  CH.sub.3                                                                             Cl     CH                                          H  C(O)cyclo-C.sub.5 H.sub.9                                                                   H  OCH.sub.3                                                                            Cl     CH                                          H  C(O)cyclo-C.sub.3 F.sub.5                                                                   H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  C(O)CF.sub.3  H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  C(O)(CH.sub.2).sub.4 F                                                                      H  CH.sub.3                                                                             Cl     CH                                          H  C(O)cyclo-(CHCH.sub.2 CCl.sub.2)                                                            H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  L-1, R.sub.h = H                                                                            H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  L-1, R.sub.h = CH.sub.3                                                                     H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  L-2, R.sub.h = H                                                                            H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  L-2, R.sub.h = CH.sub.3                                                                     H  CH.sub.3                                                                             Br     CH                                          H  L-3           H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                          H  L-4           H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                          H  L-5           H  OCH.sub.3                                                                            Cl     CH                                          H  L-6           H  CH.sub.3                                                                             CH.sub. 3                                                                            CH                                          H  L-7           H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  L-8           H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  L-9           H  CH.sub.3                                                                             Cl     CH                                          H  L-10          H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  L-11          H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  L-12          H  OCH.sub.3                                                                            Cl     CH                                          H  L-13          H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  L-14          H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  L-15          H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  L-16, R.sub.i = H                                                                           H  CH.sub.3                                                                             Cl     CH.sub.3                                    H  L-16, R.sub.i = CH.sub.3                                                                    H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  L-17          H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  L-18          H  OCH.sub.3                                                                            Cl     CH                                          H  L-19          H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  L-20          H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  L-21          H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  L-22          H  CH.sub.3                                                                             Cl     CH                                          H  L-23          H  OCH.sub.3                                                                            Cl     CH                                          H  L-24          H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  L-25          H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  L-26, R.sub.j = H                                                                           H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  L-26, R.sub.j = CH.sub.3                                                                    H  CH.sub.3                                                                             Cl     CH                                          H  L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           H  CH.sub. 3                                                                            OCH.sub.3                                                                            N                                           H  L-27, R.sub.j = H                                                                           H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  L-27, R.sub.j = CH.sub.3                                                                    H  OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                          H  L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           H  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                          H  L-28, R.sub.k = H                                                                           H  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                          H  L-28, R.sub.k = CH.sub.3                                                                    H  CH.sub.3                                                                             Br     CH                                          H  L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                          H  L-28, R.sub.k = OCH.sub.3                                                                   H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                          H  L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          H  OCH.sub.3                                                                            Cl     CH                                          H  L-28, R.sub.k = SCH.sub.3                                                                   H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  L-29, R.sub.k = H                                                                           H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  L-29, R.sub.k = CH.sub.3                                                                    H  CH.sub.3                                                                             Cl     CH                                          H  L-29, R.sub.k = CH.sub.2 CH.sub.3                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  L-29, R.sub.k = OCH.sub.3                                                                   H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          H  OCH.sub.3                                                                            Cl     CH                                          H  L-29, R.sub.k = SCH.sub.3                                                                   H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  L-29, R.sub.k = SCH.sub.2 CH.sub.3                                                          H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  L-30, R.sub.m = H                                                                           H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  L-30, R.sub.m = CH.sub.3                                                                    H  CH.sub.3                                                                             Cl     CH                                          H  L-30, R.sub.m = CH.sub.2 CH.sub.3                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            N                                           H  L-31, R.sub.m = H                                                                           H  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                           H  L-31, R.sub.m = CH.sub.3                                                                    H  OCH.sub.3                                                                            Cl     CH                                          H  L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           H  CH.sub.3                                                                             CH.sub.3                                                                             CH                                          H  L-32, R.sub.m = H                                                                           H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          H  L-32, R.sub.m = CH.sub.3                                                                    H  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                          H  L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           H  CH.sub.3                                                                             Cl     CH                                          H  L-33, R.sub.n = H                                                                           H  CH.sub.3                                                                             CH.sub.3                                                                             N                                           H  L-33, R.sub.n = CH.sub.3                                                                    H  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                          __________________________________________________________________________

                                      TABLE 6                                     __________________________________________________________________________     ##STR40##                                                                    R  R.sub.6       R.sub.7                                                                           X       Y       Z  m.p. (°C.)                     __________________________________________________________________________    H  CO.sub.2 CH.sub.3                                                                           H   H       OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Br      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              O(CH.sub.2).sub.2 CH.sub.3                                                            CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              (CH.sub.2).sub.2 CH.sub.3                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                     Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                             Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                             OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             H       CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                     CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                    CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                            CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              SCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             SCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             SCH.sub. 2 CH.sub.3                                                                   CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                     SCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              SCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                     SCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             Br      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                    Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                            Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                            CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                              Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                              CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                              OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                            Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                            CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub. 3                                                                          H   NHCH.sub.3                                                                            OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                     Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                     CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                     OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                    CH                                       CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Cl      CH                                       CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             Cl      CH                                       CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Cl      CF                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             CF                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                             CF                                       H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             CH.sub.3                                                                              CF                                       H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Cl      CCl                                      H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             CCl                                      H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Br      CBr                                      H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Cl      CBr                                      H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             CBr                                      H  CO.sub.2 CH.sub.3                                                                           H   H       OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Br      N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              O(CH.sub.2).sub.2 CH.sub.3                                                            N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              CH.sub.3                                                                              N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              (CH.sub.2).sub.2 CH.sub.3                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                     Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                             Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                             OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             H       N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             CH.sub.3                                                                              N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                     N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                    N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                            N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             Br      N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                    Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              N                                        H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                            Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                            CH.sub.3                                                                              N                                        H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                              Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                              CH.sub.3                                                                              N                                        H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                              OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                            Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                            CH.sub.3                                                                              N                                        H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                            OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                     Cl      N                                        H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                     CH.sub.3                                                                              N                                        H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                     OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                    N                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              Cl      N                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             Cl      N                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             N                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             CH.sub.3                                                                              N                                        CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                             OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           5-F OCH.sub.3                                                                             Cl      CH                                       H  CO.sub.2 CH.sub.3                                                                           3-Cl                                                                              CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.3                                                                           5-Cl                                                                              CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           3-CH.sub.3                                                                        CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.3                                                                           3-F CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  CO.sub.2 CH.sub.3                                                                           5-F CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.3                                                                           5-CH.sub.3                                                                        CH.sub.3                                                                              Br      CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                             Cl      CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              Cl      CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              Br      CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                       H  CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H   OCH.sub.3                                                                             Cl      CH                                       H  CO.sub.2 CH.sub.2 CCH                                                                       H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  CO.sub.2 CH(CH.sub.3).sub.2                                                                 H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H   CH.sub.3                                                                              Cl      CH                                       H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                       H  CO.sub.2 (CH.sub.2).sub.2 F                                                                 H   OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                       H  CO.sub.2 (CH.sub.2).sub.2 Br                                                                H   CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                       H  CO.sub.2 (CH.sub.2).sub.2 I                                                                 H   CH.sub.3                                                                              Br      CH                                       H  CO.sub.2 CH.sub.2 CF.sub.3                                                                  H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    CH                                       H  CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                       CH.sub.3                                                                         CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                             Cl      CH                                       H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  3-CH.sub.3                                                                        CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  F             H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  Cl            H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  Br            H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  CH.sub.3      H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  CH.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  (CH.sub.2).sub.2 CH.sub.3                                                                   H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  CH(CH.sub.3).sub.2                                                                          H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                       H  CHCF.sub.2    H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  CClCCl.sub.2  H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  CH.sub.2 CHCHCCl.sub.3                                                                      H   CH.sub.3                                                                              Cl      CH                                       H  CHCHCl        H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  CHCHI         H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  CHCBr.sub.2   H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                       H  CFCFH         H   OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                       H  CH.sub.2 CHCF.sub.2                                                                         H   CH.sub.2 CH.sub. 3                                                                    OCH.sub.3                                                                             CH                                       H  CHCHCF.sub.3  H   CH.sub.3                                                                              Br      CH                                       H  CFCFCH.sub.3  H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    H                                        H  OCH.sub.3     H   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                       H  OCH.sub.3     3-Cl                                                                              OCH.sub.3                                                                             Cl      CH                                       H  OCH.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  C(O)N(CH.sub.3).sub.2                                                                       H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  C(O)NHCH.sub.2 CH.sub.3                                                                     H   OCH.sub.3                                                                             Cl      CH                                       H  C(O)N(CH.sub.3)OCH.sub.3                                                                    H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  C(O)NHOCH.sub.2 CH.sub.3                                                                    H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  SO.sub.2 N(CH.sub.3).sub.2                                                                  H   CH.sub.3                                                                              Cl      CH                                       H  SO.sub.2 NHcyclopropyl                                                                      H   OCH.sub.3                                                                             Cl      CH                                       CH.sub.3                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                  H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  SO.sub.2 N(CH.sub.3).sub.2                                                                  3-CH.sub.3                                                                        CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H   CH.sub.3                                                                              Cl      CH                                       H  SO.sub.2 NH.sub.2                                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                       H  SCH.sub.3     H   OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                       H  SCH.sub.2 CHCH.sub.3                                                                        H   CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                       H  SCH.sub.2 CCH.sub.3                                                                         H   CH.sub.3                                                                              Br      CH                                       H  S(CH.sub.2).sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    CH                                       H  S(O)CH.sub.3  H   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                       H  SCF.sub.2 H   H   OCH.sub.3                                                                             Cl      CH                                       H  SCF.sub.2 CF.sub.2 H                                                                        H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  S(CH.sub.2).sub.2 Cl                                                                        H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  S(CH.sub.2).sub.2 I                                                                         H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  S(CH.sub.2).sub.3 Br                                                                        H   CH.sub.3                                                                              Cl      CH                                       H  S(O)CF.sub.2 CF.sub.2 H                                                                     H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  S(O)(CH.sub.2).sub.2 I                                                                      H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  S(O).sub.2 CH.sub.3                                                                         H   OCH.sub.3                                                                             Cl      CH                                       H  S(O).sub.2 CH.sub.2 CH.sub.3                                                                H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  S(O).sub.2 CH.sub.2 CCH                                                                     H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  S(O).sub.2 CF.sub.2 H                                                                       H   CH.sub.3                                                                              Cl      CH                                       H  S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  S(O).sub.2 (CH.sub.2).sub.2 I                                                               H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  C(O)CH.sub.3  H   OCH.sub.3                                                                             Cl      CH                                       H  C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  C(O)CH.sub.2 CH.sub.3                                                                       H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  C(O)cyclo-C.sub.3 H.sub.5                                                                   H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  C(O)cyclo-C.sub.4 H.sub.7                                                                   H   CH.sub.3                                                                              Cl      CH                                       H  C(O)cyclo-C.sub.5 H.sub.9                                                                   H   OCH.sub.3                                                                             Cl      CH                                       H  C(O)cyclo-C.sub.3 F.sub.5                                                                   H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  C(O)CF.sub.3  H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  C(O)(CH.sub.2).sub.4 F                                                                      H   CH.sub.3                                                                              Cl      CH                                       H  C(O)cyclo-(CHCH.sub.2 CCl.sub.2)                                                            H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  L-1, R.sub.h =H                                                                             H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                       H  L-1, R.sub.h =CH.sub.3                                                                      H   OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                       H  L-2, R.sub.h =H                                                                             H   CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                       H  L-2, R.sub.h =CH.sub.3                                                                      H   CH.sub.3                                                                              Br      CH                                       H  L-3           H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    CH                                       H  L-4           H   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                       H  L-5           H   OCH.sub.3                                                                             Cl      CH                                       H  L-6           H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  L-7           H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  L-8           H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  L-9           H   CH.sub.3                                                                              Cl      CH                                       H  L-10          H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  L-11          H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  L-12          H   OCH.sub.3                                                                             Cl      CH                                       H  L-13          H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  L-14          H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  L-15          H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  L-16, R.sub.i =H                                                                            H   CH.sub.3                                                                              Cl      CH                                       H  L-16, R.sub.i =CH.sub.3                                                                     H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  L-17          H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  L-18          H   OCH.sub.3                                                                             Cl      CH                                       H  L-19          H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  L-20          H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  L-21          H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  L-22          H   CH.sub.3                                                                              Cl      CH                                       H  L-23          H   OCH.sub.3                                                                             Cl      CH                                       H  L-24          H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  L-25          H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  L-26, R.sub.j =H                                                                            H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  L-26, R.sub.j =CH.sub.3                                                                     H   CH.sub.3                                                                              Cl      CH                                       H  L-26, R.sub.j =CH.sub.2 CH.sub.3                                                            H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  L-27, R.sub.j =H                                                                            H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  L-27, R.sub.j =CH.sub.3                                                                     H   OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                       H  L-27, R.sub.j =CH.sub.2 CH.sub.3                                                            H   OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                       H  L-28, R.sub.k =H                                                                            H   CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                       H  L-28, R.sub.k =CH.sub.3                                                                     H   CH.sub.3                                                                              Br      CH                                       H  L-28, R.sub.k =CH.sub.2 CH.sub.3                                                            H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    CH                                       H  L-28, R.sub.k = OCH.sub.3                                                                   H   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                       H  L-28, R.sub.k =OCH.sub.2 CH.sub.3                                                           H   OCH.sub.3                                                                             Cl      CH                                       H  L-28, R.sub.k =SCH.sub.3                                                                    H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  L-28, R.sub.k =SCH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  L-29, R.sub.k =H                                                                            H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  L-29, R.sub.k =CH.sub.3                                                                     H   CH.sub.3                                                                              Cl      CH                                       H  L-29, R.sub.k =CH.sub.2 CH.sub.3                                                            H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  L-29, R.sub.k =OCH.sub.3                                                                    H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  L-29, R.sub.k =OCH.sub.2 CH.sub.3                                                           H   OCH.sub.3                                                                             Cl      CH                                       H  L-29, R.sub.k =SCH.sub.3                                                                    H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  L-29, R.sub.k =SCH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  L-30, R.sub.m =H                                                                            H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  L-30, R.sub.m =CH.sub.3                                                                     H   CH.sub.3                                                                              Cl      CH                                       H  L-30, R.sub.m =CH.sub.2 CH.sub.3                                                            H   CH.sub.3                                                                              OCH.sub.3                                                                             N                                        H  L-31, R.sub.m =H                                                                            H   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                        H  L-31, R.sub.m =CH.sub.3                                                                     H   OCH.sub.3                                                                             Cl      CH                                       H  L-31, R.sub.m =CH.sub.2 CH.sub.3                                                            H   CH.sub.3                                                                              CH.sub.3                                                                              CH                                       H  L-32, R.sub.m =H                                                                            H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       H  L-32, R.sub.m =CH.sub.3                                                                     H   OCH.sub.3                                                                             CH.sub.3                                                                              CH                                       H  L-32, R.sub.m =CH.sub.2 CH.sub.3                                                            H   CH.sub.3                                                                              Cl      CH                                       H  L-33, R.sub.n =H                                                                            H   CH.sub.3                                                                              CH.sub.3                                                                              N                                        H  L-33, R.sub.n =CH.sub.3                                                                     H   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                       __________________________________________________________________________

                                      TABLE 7                                     __________________________________________________________________________     ##STR41##                                                                    R  R.sub.6       R.sub.7                                                                           X      Y      Z  m.p. (°C.)                       __________________________________________________________________________    H  CO.sub.2 CH.sub.3                                                                           H   H      OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Br     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub. 2 CH.sub.3                                                                          H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            H      CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             SCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             SCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Br     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CF                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CF                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                         H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CF                                         H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CCl                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Br     CBr                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     CBr                                        H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                        H  CO.sub.2 CH.sub.3                                                                           H   H      OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Br     N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            H      N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub. 3                                                                           CH.sub.2 CH.sub.3                                                                    N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Br     N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   NH.sub.2                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    Cl     N                                          H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                          H  CO.sub.2 CH.sub.3                                                                           H   N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           H   NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             Cl     N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            Cl     N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             N                                          CH.sub.3                                                                         CO.sub.2 CH.sub.3                                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           2-F OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.3                                                                           3-Cl                                                                              CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.3                                                                           2-Cl                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           3-CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.3                                                                           3-F CH.sub. 3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 CH.sub.3                                                                           2-F CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.3                                                                           2-CH.sub.3                                                                        CH.sub.3                                                                             Br     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             Cl     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             Br     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub. 2 CH.sub.3                                                                  CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.2 CCH                                                                       H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CO.sub.2 CH(CH.sub.3).sub.2                                                                 H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H   CH.sub.3                                                                             Cl     CH                                         H  CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CO.sub.2 (CH.sub.2).sub.2 F                                                                 H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CO.sub.2 (CH.sub.2).sub.2 Br                                                                H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CO.sub.2 (CH.sub.2).sub.2 I                                                                 H   CH.sub.3                                                                             Br     CH                                         H  CO.sub.2 CH.sub.2 CF.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.2 CH.sub. 3                                                                  CH                                         H  CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         CH.sub.3                                                                         CO.sub.2 CH.sub.2 CH.sub.3                                                                  H   OCH.sub.3                                                                            Cl     CH                                         H  CO.sub.2 CH.sub.2 CH.sub.3                                                                  3-CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  F             H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  Cl            H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  Br            H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CH.sub.3      H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CH.sub.2 CH.sub.3                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  (CH.sub.2).sub.2 CH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  CH(CH.sub.3).sub.2                                                                          H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CHCF.sub.2    H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  CClCCl.sub.2  H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  CH.sub.2 CHCHCCl.sub.3                                                                      H   CH.sub.3                                                                             Cl     CH                                         H  CHCHCl        H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  CHCHI         H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  CHCBr.sub.2   H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  CFCFH         H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  CH.sub.2 CHCF.sub.2                                                                         H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  CHCHCF.sub.3  H   CH.sub.3                                                                             Br     CH                                         H  CFCFCH.sub.3  H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                          H  OCH.sub.3     H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  OCH.sub.3     3-Cl                                                                              OCH.sub.3                                                                            Cl     CH                                         H  OCH.sub.2 CH.sub.3                                                                          H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)N(CH.sub.3).sub.2                                                                       H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  C(O)NHCH.sub.2 CH.sub.3                                                                     H   OCH.sub.3                                                                            Cl     CH                                         H  C(O)N(CH.sub.3)OCH.sub.3                                                                    H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)NHOCH.sub.2 CH.sub.3                                                                    H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO.sub.2 N(CH.sub.3).sub.2                                                                  H   CH.sub.3                                                                             Cl     CH                                         H  SO.sub.2 NHcyclopropyl                                                                      H   OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                  H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO.sub.2 N(CH.sub.3).sub.2                                                                  3-CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H   CH.sub.3                                                                             Cl     CH                                         H  SO.sub.2 NH.sub.2                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  SCH.sub.3     H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  SCH.sub.2 CHCH.sub.3                                                                        H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  SCH.sub.2 CCH.sub.3                                                                         H   CH.sub.3                                                                             Br     CH                                         H  S(CH.sub.2).sub.2 CH.sub.3                                                                  H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  S(O)CH.sub.3  H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  SCF.sub.2 H   H   OCH.sub.3                                                                            Cl     CH                                         H  SCF.sub.2 CF.sub.2 H                                                                        H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  S(CH.sub.2).sub.2 Cl                                                                        H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  S(CH.sub.2).sub.2 I                                                                         H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  S(CH.sub.2).sub.3 Br                                                                        H   CH.sub.3                                                                             Cl     CH                                         H  S(O)CF.sub.2 CF.sub.2 H                                                                     H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  S(O)(CH.sub.2).sub.2 I                                                                      H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  S(O).sub.2 CH.sub.3                                                                         H   OCH.sub.3                                                                            Cl     CH                                         H  S(O).sub. 2 CH.sub.2 CH.sub.3                                                               H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  S(O).sub.2 CH.sub.2 CCH                                                                     H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  S(O).sub.2 CF.sub.2 H                                                                       H   CH.sub.3                                                                             Cl     CH                                         H  S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  S(O).sub.2 (CH.sub.2).sub.2 I                                                               H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  C(O)CH.sub.3  H   OCH.sub.3                                                                            Cl     CH                                         H  C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)CH.sub.2 CH.sub.3                                                                       H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)cyclo-C.sub.3 H.sub.5                                                                   H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  C(O)cyclo-C.sub.4 H.sub.7                                                                   H   CH.sub.3                                                                             Cl     CH                                         H  C(O)cyclo-C.sub.5 H.sub.9                                                                   H   OCH.sub.3                                                                            Cl     CH                                         H  C(O)cyclo-C.sub.3 F.sub.5                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)CF.sub.3  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  C(O)(CH.sub.2).sub.4 F                                                                      H   CH.sub.3                                                                             Cl     CH                                         H  C(O)cyclo-(CHCH.sub.2 CCl.sub.2)                                                            H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-1, R.sub.h = H                                                                            H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  L-1, R.sub.h = CH.sub.3                                                                     H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  L-2, R.sub.h = H                                                                            H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  L-2, R.sub.h = CH.sub.3                                                                     H   CH.sub.3                                                                             Br     CH                                         H  L-3           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  L-4           H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  L-5           H   OCH.sub.3                                                                            Cl     CH                                         H  L-6           H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-7           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-8           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-9           H   CH.sub.3                                                                             Cl     CH                                         H  L-10          H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-11          H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-12          H   OCH.sub.3                                                                            Cl     CH                                         H  L-13          H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-14          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-15          H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-16, R.sub.i = H                                                                           H   CH.sub.3                                                                             Cl     CH                                         H  L-16, R.sub.i = CH.sub.3                                                                    H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-17          H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-18          H   OCH.sub.3                                                                            Cl     CH                                         H  L-19          H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-20          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-21          H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-22          H   CH.sub.3                                                                             Cl     CH                                         H  L-23          H   OCH.sub.3                                                                            Cl     CH                                         H  L-24          H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-25          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-26, R.sub.j = H                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-26, R.sub.j = CH.sub.3                                                                    H   CH.sub.3                                                                             Cl     CH                                         H  L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-27, R.sub.j = H                                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-27, R.sub.j = CH.sub.3                                                                    H   OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  L-28, R.sub.k = H                                                                           H   CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  L-28, R.sub.k = CH.sub.3                                                                    H   CH.sub.3                                                                             Br     CH                                         H  L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  L-28, R.sub.k = OCH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          H   OCH.sub.3                                                                            Cl     CH                                         H  L-28, R.sub.k = SCH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-29, R.sub.k = H                                                                           H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-29, R.sub.k = CH.sub.3                                                                    H   CH.sub.3                                                                             Cl     CH                                         H  L-29, R.sub.k = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-29, R.sub.k = OCH.sub.3                                                                   H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          H   OCH.sub.3                                                                            Cl     CH                                         H  L-29, R.sub.k = SCH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-29, R.sub.k = SCH.sub.2 CH.sub.3                                                          H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-30, R.sub.m =  H                                                                          H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-30, R.sub.m = CH.sub.3                                                                    H   CH.sub.3                                                                             Cl     CH                                         H  L-30, R.sub.m = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  L-31, R.sub.m = H                                                                           H   CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  L-31, R.sub.m = CH.sub.3                                                                    H   OCH.sub.3                                                                            Cl     CH                                         H  L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  L-32, R.sub.m = H                                                                           H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  L-32, R.sub.m = CH.sub.3                                                                    H   OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           H   CH.sub.3                                                                             Cl     CH                                         H  L-33, R.sub.n = H                                                                           H   CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  L-33, R.sub.n = CH.sub.3                                                                    H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         __________________________________________________________________________

                                      TABLE 8                                     __________________________________________________________________________     ##STR42##                                                                    R  R.sub.8                                                                             R.sub.9       R.sub.10                                                                            X      Y      Z  m.p. (°C.)               __________________________________________________________________________    H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     H      OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            H      CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CCl                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     H      OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub. 3                                                                          H     CH.sub.3                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            H      N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Br     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Cl    OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           F     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Br    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH.sub. 2 CH.sub.3                                                                  CH.sub.3                                                                             Cl     Cl                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           (CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Br    OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CCH                                                                       H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                                                                 H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 F                                                                 H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 Br                                                                H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 I                                                                 H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CF.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            F             H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            Cl            H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            Br            H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            NO.sub.2      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CH.sub.3      H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                          H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CHCF.sub.2    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CClCCl.sub.2  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH.sub.2 CHCHCCl.sub.3                                                                      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CHCHCl        H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CHCHI         H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CHCBr.sub.2   H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CFCFH         H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CH.sub.2 CHCF.sub.2                                                                         H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CHCHCF.sub.3  H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CFCFCH.sub.3  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                  H  CH.sub.3                                                                            OCH.sub.3     H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            OCH.sub.3     CH.sub. 3                                                                           OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)N(CH.sub.3).sub.2                                                                       H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            C(O)NHCH.sub.2 CH.sub.3                                                                     H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)N(CH.sub.3)OCH.sub.3                                                                    H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)NHOCH.sub.2 CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            SO.sub.2 NHcyclopropyl                                                                      H     OCH.sub.3                                                                            Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            SO.sub.2 NH.sub.2                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            SO.sub. 2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                     H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SCH.sub.3     H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SCH.sub.2 CHCH.sub.3                                                                        H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SCH.sub.2 CCH.sub.3                                                                         H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            S(O)CH.sub.3  H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            SCF.sub.2 H   H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            SCF.sub.2 CF.sub.2 H                                                                        H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 Cl                                                                        H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 I                                                                         H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.3 Br                                                                        H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            S(O)CF.sub.2 CF.sub.2 H                                                                     H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            S(O)(CH.sub.2).sub.2 I                                                                      H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            S(O).sub.2 CH.sub.3                                                                         H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CH.sub.3                                                                H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CCH                                                                     H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(O).sub.2 CF.sub.2 H                                                                       H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            S(O).sub.2 (CH.sub.2).sub.2 I                                                               H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            C(O)CH.sub.3  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)CH.sub.2 CH.sub.3                                                                       H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.3 H.sub.5                                                                   H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.4 H.sub.7                                                                   H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.5 H.sub.9                                                                   H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.3 F.sub.5                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)CF.sub. 3 H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.4 F                                                                      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            C(O)cycylo-(CHCH.sub.2 CCl.sub.2)                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            OCF.sub.2 H   H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-1, R.sub.h = H                                                                            H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-1, R.sub.h = CH.sub.3                                                                     H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-2, R.sub.h = H                                                                            H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-2, R.sub.h = CH.sub.3                                                                     H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            L-3           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            L-4           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            L-5           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-6           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-7           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-8           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-9           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-10          H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-11          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-12          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-13          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-14          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-15          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-16, R.sub.i = H                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-16, R.sub.i = CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-17          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-18          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-19          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-20          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-21          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-22          H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-23          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-24          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-25          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub. 3                                                                           L-26, R.sub.j = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-27, R.sub.j = H                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-27, R.sub.j = CH.sub.3                                                                    H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = H                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = CH.sub.3                                                                    H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = OCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = SCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub. 3                                                                           L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-29, R.sub.k = OCH.sub.3                                                                   H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = SCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = SCH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-31, R.sub.m =  H                                                                          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-31, R.sub.m = CH.sub.3                                                                    H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = H                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = CH.sub.3                                                                    H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-33, R.sub.n = H                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            L-33, R.sub.n = CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  CH.sub.3                                                                         (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 CH.sub.3                                                                         H     CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  H     SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   CH.sub.3      H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     Br            H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   SO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  H     OCF.sub. 2 H  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3     H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH(CH.sub.3).sub.2                                                                  CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 __________________________________________________________________________

                                      TABLE 9                                     __________________________________________________________________________     ##STR43##                                                                    R  R.sub.8                                                                             R.sub.9       R.sub.10                                                                            X      Y      Z  m.p. (°C.)               __________________________________________________________________________    H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     H      OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            H      CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           SCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub. 2 CH.sub.3                                                                          H     CH.sub.3                                                                             Cl     CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CCl                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     H      OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub. 3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            H      N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                  H  CH.sub. 3                                                                           CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Br     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Cl    OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           F     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Br    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             Cl     Cl                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           (CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Br    OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CCH                                                                       H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                                                                 H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 F                                                                 H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 Br                                                                H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 I                                                                 H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CF.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            F             H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            Cl            H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            Br            H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            NO.sub.2      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CH.sub.3      H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                          H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CHCF.sub.2    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CClCCl.sub.2  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH.sub.2 CHCHCCl.sub.3                                                                      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CHCHCl        H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CHCHI         H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CHCBr.sub.2   H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CFCFH         H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CH.sub.2 CHCF.sub.2                                                                         H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CHCHCF.sub.3  H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CFCFCH.sub.3  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                  H  CH.sub.3                                                                            OCH.sub.3     H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            OCH.sub.3     CH.sub.3                                                                            OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)N(CH.sub.3).sub.2                                                                       H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            C(O)NHCH.sub.2 CH.sub.3                                                                     H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)N(CH.sub.3)OCH.sub.3                                                                    H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)NHOCH.sub.2 CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            SO.sub.2 NHcyclopropyl                                                                      H     OCH.sub.3                                                                            Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            SO.sub.2 NH.sub.2                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SCH.sub.3     H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SCH.sub.2 CHCH.sub.3                                                                        H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SCH.sub.2 CCH.sub.3                                                                         H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            S(O)CH.sub.3  H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            SCF.sub.2 H   H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            SCF.sub.2 CF.sub.2 H                                                                        H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 Cl                                                                        H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 I                                                                         H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.3 Br                                                                        H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            S(O)CF.sub.2 CF.sub.2 H                                                                     H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            S(O)(CH.sub.2).sub.2 I                                                                      H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            S(O).sub.2 CH.sub.3                                                                         H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CH.sub.3                                                                H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CCH                                                                     H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(O).sub.2 CF.sub.2 H                                                                       H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            S(O).sub.2 (CH.sub.2).sub.2 I                                                               H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            C(O)CH.sub.3  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)CH.sub.2 CH.sub.3                                                                       H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.3 H.sub.5                                                                   H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.4 H.sub.7                                                                   H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.5 H.sub.9                                                                   H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.3 F.sub.5                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)CF.sub.3  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.4 F                                                                      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-(CHCH.sub.2 CCl.sub.2)                                                            H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            OCF.sub.2 H   H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-1, R.sub.h = H                                                                            H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-1, R.sub.h = CH.sub.3                                                                     H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-2, R.sub.h = H                                                                            H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-2, R.sub.h = CH.sub.3                                                                     H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            L-3           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            L-4           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            L-5           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-6           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-7           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-8           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-9           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-10          H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-11          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-12          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-13          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-14          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-15          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-16, R.sub.i = H                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-16, R.sub.i = CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-17          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-18          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-19          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-20          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-21          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-22          H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-23          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-24          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-25          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-27, R.sub.j = H                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-27, R.sub.j = CH.sub.3                                                                    H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = H                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = CH.sub.3                                                                    H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = OCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = SCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-29, R.sub.k = OCH.sub.3                                                                   H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = SCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = SCH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-31, R.sub.m = H                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-31, R.sub.m = CH.sub.3                                                                    H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = H                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = CH.sub.3                                                                    H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-33, R.sub.n = H                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            L-33, R.sub.n = CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  CH.sub.3                                                                         (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 CH.sub.3                                                                         H     CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  H     SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   CH.sub.3      H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     Br            H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   SO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  H     OCF.sub.2 H   H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3     H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH(CH.sub.3).sub.2                                                                  CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 __________________________________________________________________________

                                      TABLE 10                                    __________________________________________________________________________     ##STR44##                                                                    R  R.sub.8                                                                             R.sub.9       R.sub.10                                                                            X      Y      Z  m.p. (°C.)               __________________________________________________________________________    H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     H      OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH >250                            H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            H      CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             SCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub. 3                                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CCl                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     H      OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            H      N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Br     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Cl    OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           F     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Br    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub. 3                                                                  CH.sub.3                                                                             Cl     Cl                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           (CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Br    OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CCH                                                                       H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                                                                 H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 F                                                                 H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 Br                                                                H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 I                                                                 H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CF.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            F             H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            Cl            H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            Br            H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            NO.sub.2      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub. 3                                                                           CH.sub.3      H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                          H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CHCF.sub.2    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CClCCl.sub.2  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH.sub.2 CHCHCCl.sub.3                                                                      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CHCHCl        H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CHCHI         H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CHCBr.sub.2   H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CFCFH         H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CH.sub.2 CHCF.sub.2                                                                         H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CHCHCF.sub.3  H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CFCFCH.sub.3  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                  H  CH.sub.3                                                                            OCH.sub.3     H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            OCH.sub.3     CH.sub.3                                                                            OCH.sub. 3                                                                           Cl     CH                                 H  CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)N(CH.sub.3).sub.2                                                                       H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            C(O)NHCH.sub.2 CH.sub.3                                                                     H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)N(CH.sub.3)OCH.sub.3                                                                    H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)NHOCH.sub.2 CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            SO.sub.2 NHcyclopropyl                                                                      H     OCH.sub.3                                                                            Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            SO.sub.2 NH.sub.2                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)OCH.sub.3                                                               H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SCH.sub.3     H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SCH.sub.2 CHCH.sub.3                                                                        H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SCH.sub.2 CCH.sub.3                                                                         H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            S(O)CH.sub.3  H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            SCF.sub.2 H   H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            SCF.sub.2 CF.sub.2 H                                                                        H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 Cl                                                                        H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 I                                                                         H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.3 Br                                                                        H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            S(O)CF.sub.2 CF.sub.2 H                                                                     H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            S(O)(CH.sub.2).sub.2 I                                                                      H     CH.sub.3                                                                             OCH.sub.2 CH.sub. 3                                                                  N                                  H  CH.sub.3                                                                            S(O).sub.2 CH.sub.3                                                                         H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CH.sub.3                                                                H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CCH                                                                     H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(O).sub.2 CF.sub.2 H                                                                       H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            S(O).sub.2 (CH.sub.2).sub.2 I                                                               H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            C(O)CH.sub.3  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)CH.sub.2 CH.sub.3                                                                       H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.3 H.sub.5                                                                   H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.4 H.sub.7                                                                   H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.5 H.sub.9                                                                   H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.3 F.sub.5                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)CF.sub.3  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.4 F                                                                      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-(CHCH.sub.2 CCl.sub.2)                                                            H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            OCF.sub.2 H   H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-1, R.sub.h = H                                                                            H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-1, R.sub.h = CH.sub.3                                                                     H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-2, R.sub.h = H                                                                            H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-2, R.sub.h = CH.sub.3                                                                     H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            L-3           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            L-4           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            L-5           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-6           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-7           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-8           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-9           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-10          H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-11          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-12          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-13          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-14          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-15          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-16, R.sub.i = H                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-16, R.sub.i = CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-17          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-18          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-19          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-20          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-21          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-22          H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-23          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-24          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-25          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-27, R.sub.j = H                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-27, R.sub.j = CH.sub.3                                                                    H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = H                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = CH.sub.3                                                                    H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = OCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = SCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-29, R.sub.k = OCH.sub.3                                                                   H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = SCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = SCH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-30, R.sub.m =  CH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-31, R.sub.m = H                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-31, R.sub.m = CH.sub.3                                                                    H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = H                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = CH.sub.3                                                                    H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-33, R.sub.n = H                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            L-33, R.sub.n = CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub. 3                                                                           CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  CH.sub.3                                                                         (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 CH.sub.3                                                                         H     CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  H     SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   CH.sub.3      H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     Br            H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   SO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  H     OCF.sub.2 H   H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3     H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH(CH.sub.3).sub.2                                                                  CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 __________________________________________________________________________

                                      TABLE 11                                    __________________________________________________________________________     ##STR45##                                                                    R  R.sub.8                                                                             R.sub.9       R.sub.10                                                                            X      Y      Z  m.p. (°C.)               __________________________________________________________________________    H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     H      OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            H      CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                 H  CH.sub.3                                                                            CO.sub. 2 CH.sub.3                                                                          H     CH.sub.3                                                                             SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           SCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub. 2 CH.sub.3                                                                          H     NH.sub.2                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CF                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CCl                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     H      OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            H      N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Br     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NH.sub.2                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub. 2 CH.sub.3                                                                          H     N(CH.sub.3).sub.2                                                                    Cl     N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Cl    OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           F     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Br    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             Cl     Cl                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           (CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           CH(CH.sub.3).sub.2                                                                  CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           Br    OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub. 2 CH.sub.3                                                                  N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CHCH.sub.3                                                                H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CCH                                                                       H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 CH(CH.sub.3).sub.2                                                                 H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3                                                         H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2 CH.sub. 3                                               H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 OCH.sub.3                                                                 H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 Cl                                                                H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 F                                                                 H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 Br                                                                H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CO.sub.2 (CH.sub.2).sub.2 I                                                                 H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CF.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.2 CN                                                               H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 CH.sub.3                                                                         CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            F             H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            Cl            H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            Br            H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            NO.sub.2      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CH.sub.3      H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH(CH.sub.3).sub.2                                                                          H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CHCF.sub.2    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CClCCl.sub.2  H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CH.sub.2 CHCHCCl.sub.3                                                                      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            CHCHCl        H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            CHCHI         H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            CHCBr.sub.2   H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            CFCFH         H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CH.sub.2 CHCF.sub.2                                                                         H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            CHCHCF.sub.3  H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            CFCFCH.sub.3  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   H                                  H  CH.sub.3                                                                            OCH.sub.3     H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            OCH.sub.3     CH.sub.3                                                                            OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)N(CH.sub.3).sub.2                                                                       H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            C(O)NHCH.sub.2 CH.sub.3                                                                     H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)N(CH.sub.3)OCH.sub.3                                                                    H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)NHOCH.sub.2 CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)NH(CH.sub.2).sub.2 CH.sub.3                                                             H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            SO.sub.2 NHcyclopropyl                                                                      H     OCH.sub.3                                                                            Cl     CH                                 CH.sub.3                                                                         CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)CH.sub.2 CHCH.sub.2                                                     H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SO.sub.2 N((CH.sub.2).sub.2 CH.sub.3).sub.2                                                 H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            SO.sub.2 NH.sub.2                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)OCH.sub. 3                                                              H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3                                                      H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            SCH.sub.3     H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SCH.sub.2 CHCH.sub.3                                                                        H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            SCH.sub.2 CCH.sub.3                                                                         H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            S(O)CH.sub.3  H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            SCF.sub.2 H   H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            SCF.sub.2 CF.sub.2 H                                                                        H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 Cl                                                                        H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.2 I                                                                         H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(CH.sub.2).sub.3 Br                                                                        H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            S(O)CF.sub.2 CF.sub.2 H                                                                     H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            S(O)(CH.sub.2).sub.2 I                                                                      H     CH.sub.3                                                                             OCH.sub.2 CH.sub. 3                                                                  N                                  H  CH.sub.3                                                                            S(O).sub.2 CH.sub.3                                                                         H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CH.sub.3                                                                H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CHCH.sub.2                                                              H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            S(O).sub.2 CH.sub.2 CCH                                                                     H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            S(O).sub.2 CF.sub.2 H                                                                       H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            S(O).sub.2 CF.sub.2 CF.sub.2 H                                                              H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            S(O).sub.2 (CH.sub.2).sub.2 I                                                               H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            C(O)CH.sub.3  H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.3 CH.sub.3                                                               H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)CH.sub.2 CH.sub.3                                                                       H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.3 H.sub.5                                                                   H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.4 H.sub.7                                                                   H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.5 H.sub.9                                                                   H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-C.sub.3 F.sub.5                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)CF.sub.3  H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.3 CCl.sub.2 H                                                            H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            C(O)(CH.sub.2).sub.4 F                                                                      H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            C(O)cyclo-(CHCH.sub.2 CCl.sub.2)                                                            H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            OCF.sub.2 H   H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-1, R.sub.h = H                                                                            H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-1, R.sub.h = CH.sub.3                                                                     H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-2, R.sub.h = H                                                                            H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-2, R.sub.h = CH.sub.3                                                                     H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            L-3           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            L-4           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            L-5           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-6           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-7           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-8           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-9           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-10          H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-11          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-12          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-13          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-14          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-15          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-16, R.sub.i = H                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-16, R.sub.i = CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-17          H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-18          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-19          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-20          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-21          H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-22          H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-23          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-24          H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-25          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-26, R.sub.j = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-27, R.sub.j = H                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-27, R.sub.j = CH.sub.3                                                                    H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-27, R.sub.j = CH.sub.2 CH.sub.3                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = H                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = CH.sub.3                                                                    H     CH.sub.3                                                                             Br     CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = OCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = OCH.sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = SCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-28, R.sub.k = SCH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-29, R.sub.k = OCH.sub.3                                                                   H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-29, R.sub.k = OCH.sub.2 CH.sub.3                                                          H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = SCH.sub.3                                                                   H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-29, R.sub.k = SCH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = H                                                                           H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-30, R.sub.m = CH.sub.3                                                                    H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-30, R.sub.m =  CH.sub.2 CH.sub.3                                                          H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  CH.sub.3                                                                            L-31, R.sub.m = H                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH.sub.3                                                                            L-31, R.sub.m = CH.sub.3                                                                    H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.3                                                                            L-31, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = H                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = CH.sub.3                                                                    H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.3                                                                            L-32, R.sub.m = CH.sub.2 CH.sub.3                                                           H     CH.sub.3                                                                             Cl     CH                                 H  CH.sub.3                                                                            L-33, R.sub.n = H                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             N                                  H  CH.sub.3                                                                            L-33, R.sub.n = CH.sub.3                                                                    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     OCH.sub. 3                                                                           CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             Cl     CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                  H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  CH.sub.3                                                                         (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                 CH.sub.3                                                                         H     CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Br     CH                                 H  (CH.sub.2).sub.2 CH.sub.3                                                           CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                 H  H     CO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                 H  CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 H  H     SO.sub.2 N(CH.sub.3).sub.2                                                                  H     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   CH.sub.3      H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 H  H     Br            H     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 H  CH.sub.2 CH.sub.3                                                                   SO.sub.2 CH.sub.3                                                                           H     CH.sub.3                                                                             Cl     CH                                 H  H     OCF.sub.2 H   H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  H  (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3     H     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                  H  CH(CH.sub.3).sub.2                                                                  CO.sub.2 CH.sub.3                                                                           H     OCH.sub.3                                                                            Cl     CH                                 __________________________________________________________________________

                                      TABLE 12                                    __________________________________________________________________________     ##STR46##                                                                    R  Q  R.sub.11                                                                           R.sub.12                                                                           R.sub.14                                                                           X      Y      Z  m.p. (°C.)                       __________________________________________________________________________    H  O  CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                         H  O  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            N                                          H  O  CH.sub.2                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                         H  O  CH.sub.2                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   SCH.sub.3                                                                            N                                          H  O  CH.sub.2                                                                           H    H    N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                         H  O  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     CH                                         H  O  CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     CH                                         H  O  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                         H  O  CH.sub. 3                                                                          H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     CH                                         H  O  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                         CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CF                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CF                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                         H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                         H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CCl                                        H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                        H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CBr                                        H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CBr                                        H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                        H  O  CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     N                                          H  O  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                          H  O  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                          H  O  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                          H  O  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                          H  O  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     N                                          H  O  CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             N                                          H  O  CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     N                                          H  O  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                          H  O  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     N                                          H  O  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                          H  O  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          CH.sub.3                                                                         O  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  O  H    H    H    OCH.sub.3                                                                            Cl     CH                                         H  O  CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  O  CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  O  CH.sub.2 CH.sub.3                                                                  H    H    CH.sub.3                                                                             Cl     CH                                         H  O  CH.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  O  H    CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         O  H    H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  O  H    H    5-F  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           H    6-F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  O  H    CH.sub.3                                                                           5-Cl CH.sub.3                                                                             Br     CH                                         H  O  CH.sub.3                                                                           CH.sub.3                                                                           6-Cl CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  O  H    H    5-Br CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  O  CH.sub.3                                                                           H    6-Br OCH.sub.3                                                                            Cl     CH                                         H  O  H    CH.sub.3                                                                           5-CN CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           CH.sub.3                                                                           6-CN CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  O  H    H    5-CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  O  CH.sub.3                                                                           H    6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     CH                                         H  O  H    CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  O  CH.sub.3                                                                           CH.sub.3                                                                           6-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  O  H    H    5-SCH.sub. 3                                                                       OCH.sub.3                                                                            Cl     CH                                         H  O  CH.sub.3                                                                           H    6-SCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  O  H    CH.sub.3                                                                           5-OCF.sub.2 H                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  O  CH.sub.3                                                                           CH.sub.3                                                                           6-OCF.sub.2 H                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         O  CH.sub.3                                                                           H    6-Cl CH.sub.3                                                                             Cl     CH                                         H  S  CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                         H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           SCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                         H  S  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     CH                                         H  S  CH.sub. 3                                                                          H    H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                         H  S  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     CH                                         H  S  CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     CH                                         H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     CH                                         H  S  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                         CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CF                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CF                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                         H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                         H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CCl                                        H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                        H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CBr                                        H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CBr                                        H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                        H  S  CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     N                                          H  S  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                          H  S  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  S  CH.sub. 3                                                                          H    H    OCH.sub.3                                                                            Cl     N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                          H  S  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                          H  S  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                          H  S  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     N                                          H  S  CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             N                                          N  S  CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     N                                          H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                          H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     N                                          H  S  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                          H  S  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          CH.sub.3                                                                         S  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  S  H    H    H    OCH.sub.3                                                                            Cl     CH                                         H  S  CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  S  CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  S  CH.sub.2 CH.sub.3                                                                  H    H    CH.sub.3                                                                             Cl     CH                                         H  S  CH.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  S  H    CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         S  H    H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  S  H    H    5-F  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           H    6-F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  S  H    CH.sub.3                                                                           5-Cl CH.sub.3                                                                             Br     CH                                         H  S  CH.sub.3                                                                           CH.sub.3                                                                           6-Cl CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  S  H    H    5-Br CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  S  CH.sub.3                                                                           H    6-Br OCH.sub.3                                                                            Cl     CH                                         H  S  H    CH.sub.3                                                                           5-CN CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           CH.sub.3                                                                           6-CN CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  S  H    H    5-CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  S  CH.sub.3                                                                           H    6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     CH                                         H  S  H    CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  S  CH.sub.3                                                                           CH.sub.3                                                                           6-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  S  H    H    5-SCH.sub.3                                                                        OCH.sub.3                                                                            Cl     CH                                         H  S  CH.sub.3                                                                           H    6-SCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  S  H    CH.sub.3                                                                           5-OCF.sub.2 H                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  S  CH.sub.3                                                                           CH.sub.3                                                                           6-OCF.sub.2 H                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         S  CH.sub.3                                                                           H    6-Cl CH.sub.3                                                                             Cl     CH                                         H  SO CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    NH.sub.2                                                                             SCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    (CH.sub.2).sub. 2 CH.sub.3                                                           Cl     CH                                         H  SO CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                         H  SO CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     CH                                         H  SO CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     CH                                         H  SO CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     CH                                         H  SO CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                         CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CF                                         H  SO CH.sub.3                                                                           H    H    CH.sub. 3                                                                            OCH.sub.3                                                                            CF                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                         H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                         H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CCl                                        H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                        H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CBr                                        H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CBr                                        H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                        H  SO CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     N                                          H  SO CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                          H  SO CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                          H  SO CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                          H  SO CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                          H  SO CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     N                                          H  SO CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             N                                          H  SO CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     N                                          H  SO CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                          H  SO CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     N                                          H  SO CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                          H  SO CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          CH.sub.3                                                                         SO CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  SO H    H    H    OCH.sub.3                                                                            Cl     CH                                         H  SO CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO CH.sub.2 CH.sub.3                                                                  H    H    CH.sub.3                                                                             Cl     CH                                         H  SO CH.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  SO H    CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         SO H    H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  SO H    H    5-F  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           H    6-F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  SO H    CH.sub.3                                                                           5-Cl CH.sub.3                                                                             Br     CH                                         H  SO CH.sub.3                                                                           CH.sub.3                                                                           6-Cl CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  SO H    H    5-Br CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  SO CH.sub.3                                                                           H    6-Br OCH.sub.3                                                                            Cl     CH                                         H  SO H    CH.sub.3                                                                           5-CN CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           CH.sub.3                                                                           6-CN CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO H    H    5-CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO CH.sub.3                                                                           H    6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     CH                                         H  SO H    CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  SO CH.sub.3                                                                           CH.sub.3                                                                           6-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  SO H    H    5-SCH.sub.3                                                                        OCH.sub.3                                                                            Cl     CH                                         H  SO CH.sub.3                                                                           H    6-SCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO H    CH.sub.3                                                                           5-OCF.sub.2 H                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO CH.sub.3                                                                           CH.sub.3                                                                           6-OCF.sub.2 H                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         SO CH.sub.3                                                                           H    6-Cl CH.sub.3                                                                             Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH 240-250                                 H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  SO.sub. 2                                                                        CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         SO.sub.3                                                                           H    H    OCH.sub.3                                                                            H      CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NH.sub. 2                                                                            CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                         CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CF                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CF                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub. 3                                                                           OCH.sub.3                                                                            CF                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CCl                                        H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                        H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CBr                                        H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CBr                                        H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                        H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.2 CH.sub. 3                                                                   Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub. 2 CH.sub.3                                                                  OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         H    H    H    OCH.sub.3                                                                            Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.2 CH.sub.3                                                                  H    H    CH.sub.3                                                                             Cl     CH                                         H  SO.sub.2                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         H    CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         SO.sub.2                                                                         H    H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         H    H    5-F  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    6-F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         H    CH.sub.3                                                                           5-Cl CH.sub. 3                                                                            Br     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           CH.sub.3                                                                           6-Cl CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  SO.sub.2                                                                         H    H    5-Br CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    6-Br OCH.sub.3                                                                            Cl     CH                                         H  SO.sub.2                                                                         H    CH.sub.3                                                                           5-CN CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           CH.sub.3                                                                           6-CN CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         H    H    5-CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     CH                                         H  SO.sub.2                                                                         H    CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  SO.sub.2                                                                         CH.sub.3                                                                           CH.sub.3                                                                           6-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  SO.sub.2                                                                         H    H    5-SCH.sub.3                                                                        OCH.sub.3                                                                            Cl     CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           H    6-SCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  SO.sub.2                                                                         H    CH.sub.3                                                                           5-OCF.sub.2 H                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  SO.sub.2                                                                         CH.sub.3                                                                           CH.sub.3                                                                           6-OCF.sub.2 H                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         SO.sub.2                                                                         CH.sub.3                                                                           H    6-Cl CH.sub.3                                                                             Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.2 CH.sub.3                                                                   N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                         CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                         CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                         CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CF                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CF                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                         H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CCl                                        H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                        H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CBr                                        H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CBr                                        H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                        H  C(O)                                                                             CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     N                                          H  C(O)                                                                             CH.sub. 3                                                                          H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    OCH CH.sub.3                                                                         Cl     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    O(CH.sub.2).sub.3 CH.sub.3                                                           Cl     N                                          H  C(O)                                                                             CH.sub. 3                                                                          H    H    O(CH.sub.2).sub.3 CH.sub.3                                                           CH.sub.3                                                                             N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    O(CH.sub.2).sub.3 CH.sub.3                                                           OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                          CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                          CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                          CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub. 3                                                                            N                                          CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                          H  C(O)                                                                             H    H    H    OCH.sub.3                                                                            Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.2 CH.sub.3                                                                  H    H    CH.sub.3                                                                             Cl     CH                                         H  C(O)                                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  C(O)                                                                             H    CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          CH.sub.3                                                                         C(O)                                                                             H    H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                         H  C(O)                                                                             H    H    5-F  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    6-F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                         H  C(O)                                                                             H    CH.sub.3                                                                           5-Cl CH.sub.3                                                                             Br     CH                                         H  C(O)                                                                             CH.sub.3                                                                           CH.sub.3                                                                           6-Cl CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                         H  C(O)                                                                             H    H    5-Br CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    6-Br OCH.sub.3                                                                            Cl     CH                                         H  C(O)                                                                             H    CH.sub.3                                                                           5-CN CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub. 3                                                                          CH.sub.3                                                                           6-CN CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)                                                                             H    H    5-CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     CH                                         H  C(O)                                                                             H    CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                          H  C(O)                                                                             CH.sub.3                                                                           CH.sub.3                                                                           6-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                          H  C(O)                                                                             H    H    5-SCH.sub.3                                                                        OCH.sub.3                                                                            Cl     CH                                         H  C(O)                                                                             CH.sub.3                                                                           H    6-SCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                         H  C(O)                                                                             H    CH.sub.3                                                                           5-OCF.sub.2 H                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                         H  C(O)                                                                             CH.sub.3                                                                           CH.sub.3                                                                           6-OCF.sub.2 H                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                         CH.sub.3                                                                         C(O)                                                                             CH.sub.3                                                                           H    6-Cl CH.sub.3                                                                             Cl     CH                                         __________________________________________________________________________

                                      TABLE 13                                    __________________________________________________________________________     ##STR47##                                                                    R  R.sub.11                                                                           R.sub.12                                                                           R.sub.14                                                                           X      Y      Z  m.p. (°C.)                          __________________________________________________________________________    H  CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     CH                                            H  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                            H  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                            H  CH   H    H    CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           SCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                            H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     CH                                            H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     CH                                            H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    N(CH.sub. 3).sub.2                                                                   OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CF                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CF                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CCl                                           H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                           H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CBr                                           H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CBr                                           H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                           H  CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    CH.sub. 3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                             H  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     N                                             H  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                             H  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     N                                             H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                             H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                             H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     N                                             H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     N                                             H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     N                                             H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                             H  H    H    H    OCH.sub.3                                                                            Cl     CH                                            H  CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  CH.sub.2 CH.sub.3                                                                  H    H    CH.sub.3                                                                             Cl     CH                                            H  CH.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  H    CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  H    H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                            H  H    H    5-F  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    6-F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                            H  H    CH.sub.3                                                                           5-Cl CH.sub.3                                                                             Br     CH                                            H  CH.sub.3                                                                           CH.sub.3                                                                           6-Cl CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                            H  H    H    5-Br CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                            H  CH.sub.3                                                                           H    6-Br OCH.sub.3                                                                            Cl     CH                                            H  H    CH.sub.3                                                                           5-CN CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           CH.sub.3                                                                           6-CN CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  H    H    5-CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     CH                                            H  H    CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           CH.sub.3                                                                           6-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  H    H    5-SCH.sub.3                                                                        OCH.sub.3                                                                            Cl     CH                                            H  CH.sub.3                                                                           H    6-SCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  H    CH.sub.3                                                                           5-OCF.sub.2 H                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           CH.sub.3                                                                           6-OCF.sub.2 H                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    6-Cl CH.sub.3                                                                             Cl     CH                                            __________________________________________________________________________

                                      TABLE 14                                    __________________________________________________________________________     ##STR48##                                                                    R  R.sub.13  R.sub.14                                                                           X      Y      Z  m.p. (°C.)                          __________________________________________________________________________    H  CH.sub.3  H    H      OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    CH.sub.3                                                                             Cl     CH                                            H  CH.sub.3  H    CH.sub.3                                                                             Br     CH                                            H  CH.sub.3  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3  H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                            H  CH.sub.3  H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3  H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                            H  CH.sub.3  H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                            H  CH.sub.3  H    CH.sub.2 CH.sub.3                                                                    Cl     CH                                            H  CH.sub.3  H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                            H  CH.sub.3  H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            H      CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3  H    CH.sub.3                                                                             SCH.sub.3                                                                            CH                                            H  CH.sub.3  H    CH.sub.3                                                                             SCH.sub.3                                                                            N                                             H  CH.sub.3  H    CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                                                            CH                                            H  CH.sub.3  H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            SCH.sub.3                                                                            N                                             H  CH.sub.3  H    N(CH.sub.3).sub.2                                                                    SCH.sub.3                                                                            N                                             H  CH.sub.3  H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                            H  CH.sub.3  H    OCH.sub.3                                                                            Cl     CH                                            H  CH.sub. 3 H    OCH.sub.3                                                                            Br     CH                                            H  CH.sub.3  H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                            H  CH.sub.3  H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                            H  CH.sub.3  H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                            H  CH.sub.3  H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                            H  CH.sub.3  H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    NH.sub.2                                                                             Cl     CH                                            H  CH.sub.3  H    NH.sub.2                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3  H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    NHCH.sub.3                                                                           Cl     CH                                            H  CH.sub.3  H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                            H  CH.sub.3  H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    N(CH.sub.3).sub.2                                                                    Cl     CH                                            H  CH.sub.3  H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                            H  CH.sub.3  H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                            CH.sub.3                                                                         CH.sub.3  H    CH.sub.3                                                                             Cl     CH                                            CH.sub.3                                                                         CH.sub.3  H    OCH.sub.3                                                                            Cl     CH                                            CH.sub.3                                                                         CH.sub.3  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            CH.sub. 3                                                                        CH.sub.3  H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            CH.sub.3                                                                         CH.sub.3  H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3  H    CH.sub.3                                                                             Cl     CF                                            H  CH.sub.3  H    CH.sub.3                                                                             OCH.sub.3                                                                            CF                                            H  CH.sub.3  H    OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                            H  CH.sub.3  H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                            H  CH.sub.3  H    CH.sub.3                                                                             Cl     CCl                                           H  CH.sub.3  H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                           H  CH.sub.3  H    CH.sub.3                                                                             Br     CBr                                           H  CH.sub.3  H    CH.sub.3                                                                             Cl     CBr                                           H  CH.sub.3  H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                           H  CH.sub.3  H    H      OCH.sub.3                                                                            N                                             H  CH.sub.3  H    CH.sub.3                                                                             Cl     N                                             H  CH.sub.3  H    CH.sub.3                                                                             Br     N                                             H  CH.sub.3  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  CH.sub.3  H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  CH.sub.3  H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                             H  CH.sub.3  H    CH.sub.3                                                                             CH.sub.3                                                                             N                                             H  CH.sub.3  H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                             H  CH.sub.3  H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                             H  CH.sub.3  H    CH.sub.2 CH.sub.3                                                                    Cl     N                                             H  CH.sub.3  H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                             H  CH.sub.3  H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                             H  CH.sub.3  H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                             H  CH.sub.3  H    OCH.sub.3                                                                            H      N                                             H  CH.sub.3  H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                             H  CH.sub.3  H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                             H  CH.sub.3  H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                             H  CH.sub.3  H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                             H  CH.sub.3  H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                             H  CH.sub.3  H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                             H  CH.sub.3  H    OCH.sub.3                                                                            Cl     N                                             H  CH.sub.3  H    OCH.sub.3                                                                            Br     N                                             H  CH.sub.3  H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                             H  CH.sub.3  H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                             H  CH.sub.3  H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                             H  CH.sub.3  H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                             H  CH.sub.3  H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                             H  CH.sub.3  H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                             H  CH.sub.3  H    NH.sub.2                                                                             Cl     N                                             H  CH.sub.3  H    NH.sub.2                                                                             CH.sub.3                                                                             N                                             H  CH.sub.3  H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                             H  CH.sub.3  H    NHCH.sub.3                                                                           Cl     N                                             H  CH.sub.3  H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                             H  CH.sub.3  H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                             H  CH.sub.3  H    N(CH.sub.3).sub.2                                                                    Cl     N                                             H  CH.sub.3  H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                             H  CH.sub.3  H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                             H  CH.sub.3  H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                             CH.sub.3                                                                         CH.sub.3  H    CH.sub.3                                                                             Cl     N                                             CH.sub.3                                                                         CH.sub.3  H    OCH.sub.3                                                                            Cl     N                                             CH.sub.3                                                                         CH.sub.3  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             CH.sub.3                                                                         CH.sub.3  H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                             CH.sub.3                                                                         CH.sub.3  H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                             CH.sub.3                                                                         CH.sub.3  H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                             H  CH.sub.2 CH.sub.3                                                                       H    OCH.sub.3                                                                            Cl     CH                                            H  (CH.sub.2).sub.2 CH.sub.3                                                               H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  (CH.sub.2).sub.3 CH.sub.3                                                               H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  (CH.sub.2).sub.4 CH.sub.3                                                               H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  (CH.sub.2).sub. 5 CH.sub.3                                                              H    CH.sub.3                                                                             Cl     CH                                            H  CF.sub.2 H                                                                              CH.sub.3                                                                           OCH.sub.3                                                                            N                                                    H  (CH.sub.2).sub.2 Br                                                                     H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  (CH.sub.2).sub.4 F                                                                      H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                            H  (CH.sub.2).sub.3 Cl                                                                     H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CF.sub.2 CF.sub.2 H                                                                     H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                            H  CH.sub.2 OCH.sub.3                                                                      H    CH.sub.3                                                                             Br     CH                                            H  (CH.sub.2).sub.2 OCH.sub.3                                                              H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                            H  (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                     H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                            H  CH.sub.2 O(CH.sub.2).sub.2 CH.sub.3                                                     H    OCH.sub.3                                                                            Cl     CH                                            H  cyclopropyl                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  cyclobutyl                                                                              H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  cyclomethyl                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  cyclopropylmethyl                                                                       H    CH.sub.3                                                                             Cl     CH                                            H  cyclobutylmethyl                                                                        H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  cyclopentylmethyl                                                                       H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  2-cyclopropylethyl                                                                      H    OCH.sub.3                                                                            Cl     CH                                            CH.sub.3                                                                         (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                     H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  H         5-F  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3  6-F  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  (CH.sub.2).sub.2 OCH.sub.3                                                              5-Cl CH.sub.3                                                                             Cl     CH                                            H  cyclopropylmethyl                                                                       6-Cl CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  CH.sub.2 CH.sub.3                                                                       5-Br CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  CF.sub.2 CF.sub.2 H                                                                     6-Br OCH.sub.3                                                                            Cl     CH                                            H  H         5-CN CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3  6-CN CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  CH.sub.3  6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     CH                                            H  (CH.sub.2).sub.2 Cl                                                                     5-OCH.sub.3                                                                        OCH.sub.3                                                                            Cl     CH                                            H  CH.sub.3  6-OCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  H         5-SCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3  6-SCH.sub.3                                                                        OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  H         5-OCF.sub.2 H                                                                      CH.sub.3                                                                             Cl     CH                                            H  CH.sub.3  6-OCF.sub.2 H                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  H         H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             CH.sub.3                                                                         H         H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                            CH.sub.3                                                                         CH.sub.3  6-Br OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            CH.sub.3                                                                         (CH.sub.2).sub.2 OCH.sub.3                                                              5-F  CH.sub. 2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                            __________________________________________________________________________

                                      TABLE 15                                    __________________________________________________________________________     ##STR49##                                                                    R  R.sub.11                                                                           R.sub.12                                                                           R.sub.14                                                                           X      Y      Z  m.p. (°C.)                          __________________________________________________________________________    H  CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub. 3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     CH                                            H  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     CH                                            H  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             SCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            SCH.sub.2 CH.sub.3                                                                   CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           SCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     CH                                            H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     CH                                            H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     CH                                            H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             CH                                            H  CH.sub. 3                                                                          H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CF                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CF                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            CF                                            H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             CF                                            H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CCl                                           H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CCl                                           H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     CBr                                           H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     CBr                                           H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            CBr                                           H  CH.sub.3                                                                           H    H    H      OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             Br     N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  CH.sub. 3                                                                          H    H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                           N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                    N                                             H  CH.sub.3                                                                           H    H    CH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                            N                                             H  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    Cl     N                                             H  CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            Cl     N                                             H  CH.sub.3                                                                           H    H    (CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            H      N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                    N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            (CH.sub.2).sub.2 CH.sub.3                                                            N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            O(CH.sub.2).sub.2 CH.sub.3                                                           N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                             H  CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Br     N                                             H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   Cl     N                                             H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           Cl     N                                             H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    O(CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             Cl     N                                             H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    NH.sub.2                                                                             OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           Cl     N                                             H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    Cl     N                                             H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    CH.sub.3                                                                             N                                             H  CH.sub.3                                                                           H    H    N(CH.sub.3).sub.2                                                                    OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           H    H    NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             Cl     N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            Cl     N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            CH.sub.3                                                                             N                                             CH.sub.3                                                                         CH.sub.3                                                                           H    H    OCH.sub.3                                                                            OCH.sub.3                                                                            N                                             H  H    H    H    OCH.sub.3                                                                            Cl     CH                                            H  CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                           H    OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  CH.sub.2 CH.sub.3                                                                  H    H    CH.sub.3                                                                             Cl     CH                                            H  CH.sub.2 CH.sub.3                                                                  CH.sub.2 CH.sub.3                                                                  H    CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  H    CH.sub.3                                                                           H    CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  H    H    H    OCH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH                                            H  H    H    5-F  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           H    6-F  CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            CH                                            H  H    CH.sub.3                                                                           5-Cl CH.sub.3                                                                             Br     CH                                            H  CH.sub.3                                                                           CH.sub.3                                                                           6-Cl CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   CH                                            H  H    H    5-Br CH.sub.3                                                                             CH.sub. 2 CH.sub.3                                                                   CH                                            H  CH.sub.3                                                                           H    6-Br OCH.sub.3                                                                            Cl     CH                                            H  H    CH.sub.3                                                                           5-CN CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           CH.sub.3                                                                           6-CN CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  H    H    5-CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            H  CH.sub.3                                                                           H    6-CH.sub.3                                                                         CH.sub.3                                                                             Cl     CH                                            H  H    CH.sub.3                                                                           5-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                            N                                             H  CH.sub.3                                                                           CH.sub.3                                                                           6-OCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                   N                                             H  H    H    5-SCH.sub.3                                                                        OCH.sub.3                                                                            Cl     CH                                            H  CH.sub.3                                                                           H    6-SCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                             CH                                            H  H    CH.sub.3                                                                           5-OCF.sub.2 H                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                            H  CH.sub.3                                                                           CH.sub.3                                                                           6-OCF.sub.2 H                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                            CH.sub.3                                                                         CH.sub.3                                                                           H    6-Cl CH.sub.3                                                                             Cl     CH                                            __________________________________________________________________________

                                      TABLE 16                                    __________________________________________________________________________     ##STR50##                                                                    R   R.sub.11                                                                             R.sub.14                                                                             X       Y       Z   m.p. (°C.)                       __________________________________________________________________________    H   CH.sub.3                                                                             H      H       OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              Cl      CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              Br      CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              O(CH.sub.2).sub.2 CH.sub.3                                                            CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              (CH.sub.2).sub. 2 CH.sub.3                                                            CH                                          H   CH.sub.3                                                                             H      CH.sub.2 CH.sub.3                                                                     Cl      CH                                          H   CH.sub.3                                                                             H      CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      (CH.sub.2).sub.2 CH.sub.3                                                             Cl      CH                                          H   CH.sub.3                                                                             H      (CH.sub.2).sub.2 CH.sub.3                                                             OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             H       CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                     CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                             CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                    CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              SCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             SCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              SCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              SCH.sub.2 CH.sub.3                                                                    CH                                          H   CH.sub.3                                                                             H      CH.sub.2 CH.sub.3                                                                     SCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              SCH.sub.2 CH.sub.3                                                                    N                                           H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            SCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                            CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             Cl      CH                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             Br      CH                                          H   CH.sub.3                                                                             H      OCH.sub.2 CH.sub.3                                                                    Cl      CH                                          H   CH.sub.3                                                                             H      OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             H      OCH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      O(CH.sub.2).sub.2 CH.sub.3                                                            Cl      CH                                          H   CH.sub.3                                                                             H      O(CH.sub.2).sub.2 CH.sub.3                                                            CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             H      O(CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      NH.sub.2                                                                              Cl      CH                                          H   CH.sub.3                                                                             H      NH.sub.2                                                                              CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             H      NH.sub.2                                                                              OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            Cl      CH                                          H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      N(CH.sub.3).sub.2                                                                     Cl      CH                                          H   CH.sub.3                                                                             H      N(CH.sub.3).sub.2                                                                     CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             H      N(CH.sub.3).sub.2                                                                     OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                    CH                                          CH.sub.3                                                                          CH.sub.3                                                                             H      CH.sub.3                                                                              Cl      CH                                          CH.sub.3                                                                          CH.sub.3                                                                             H      OCH.sub.3                                                                             Cl      CH                                          CH.sub.3                                                                          CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub. 3                                                                            CH                                          CH.sub.3                                                                          CH.sub.3                                                                             H      OCH.sub.3                                                                             CH.sub.3                                                                              CH                                          CH.sub.3                                                                          CH.sub.3                                                                             H      OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              Cl      CF                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.3                                                                             CF                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             OCH.sub.3                                                                             CF                                          H   CH.sub.3                                                                             H      OCH.sub.3                                                                             CH.sub.3                                                                              CF                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              Cl      CCl                                         H   CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.3                                                                             CCl                                         H   CH.sub.3                                                                             H      CH.sub.3                                                                              Br      CBr                                         H   CH.sub.3                                                                             H      CH.sub.3                                                                              Cl      CBr                                         H   CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.3                                                                             CBr                                         H   CH.sub.3                                                                             H      H       OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              Cl      N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              Br      N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              O(CH.sub.2).sub.2 CH.sub.3                                                            N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              CH.sub.3                                                                              N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     N                                           H   CH.sub.3                                                                             H      CH.sub.3                                                                              (CH.sub.2).sub.2 CH.sub.3                                                             N                                           H   CH.sub.3                                                                             H      CH.sub.2 CH.sub.3                                                                     Cl      N                                           H   CH.sub.3                                                                             H      CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      (CH.sub.2).sub.2 CH.sub.3                                                             Cl      N                                           H   CH.sub.3                                                                             H      (CH.sub.2).sub.2 CH.sub.3                                                             OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             H       N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             CH.sub.3                                                                              N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                     N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             (CH.sub.2).sub.2 CH.sub.3                                                             N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                    N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             O(CH.sub.2).sub.2 CH.sub.3                                                            N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             Cl      N                                           H   CH.sub.3                                                                             H      OCH.sub.3                                                                             Br      N                                           H   CH.sub.3                                                                             H      OCH.sub.2 CH.sub.3                                                                    Cl      N                                           H   CH.sub.3                                                                             H      OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              N                                           H   CH.sub.3                                                                             H      OCH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      O(CH.sub.2).sub.2 CH.sub.3                                                            Cl      N                                           H   CH.sub.3                                                                             H      O(CH.sub.2).sub.2 CH.sub.3                                                            CH.sub.3                                                                              N                                           H   CH.sub.3                                                                             H      O(CH.sub.2).sub.2 CH.sub.3                                                            OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      NH.sub. 2                                                                             Cl      N                                           H   CH.sub.3                                                                             H      NH.sub.2                                                                              CH.sub.3                                                                              N                                           H   CH.sub.3                                                                             H      NH.sub.2                                                                              OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            Cl      N                                           H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            CH.sub.3                                                                              N                                           H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      N(CH.sub.3).sub.2                                                                     Cl      N                                           H   CH.sub.3                                                                             H      N(CH.sub.3).sub.2                                                                     CH.sub.3                                                                              N                                           H   CH.sub.3                                                                             H      N(CH.sub.3).sub.2                                                                     OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             H      NHCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                    N                                           CH.sub.3                                                                          CH.sub.3                                                                             H      CH.sub.3                                                                              Cl      N                                           CH.sub.3                                                                          CH.sub.3                                                                             H      OCH.sub.3                                                                             Cl      N                                           CH.sub.3                                                                          CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.3                                                                             N                                           CH.sub.3                                                                          CH.sub.3                                                                             H      CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             N                                           CH.sub.3                                                                          CH.sub.3                                                                             H      OCH.sub.3                                                                             CH.sub.3                                                                              N                                           CH.sub.3                                                                          CH.sub.3                                                                             H      OCH.sub.3                                                                             OCH.sub.3                                                                             N                                           H   H      H      OCH.sub.3                                                                             Cl      CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             H      CH.sub.3                                                                              OCH.sub.3                                                                             CH                                          H   CH.sub.2 CH.sub.3                                                                    H      OCH.sub.3                                                                             CH.sub.3                                                                              CH                                          H   CH.sub.2 CH.sub.3                                                                    H      CH.sub.3                                                                              Cl      CH                                          H   CH.sub.2 CH.sub. 3                                                                   H      CH.sub.3                                                                              OCH.sub.3                                                                             N                                           H   H      H      CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                           H   H      H      OCH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                              CH                                          H   H      5-F    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             6-F    CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH                                          H   H      5-Cl   CH.sub.3                                                                              Br      CH                                          H   CH.sub.3                                                                             6-Cl   CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    CH                                          H   H      5-Br   CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH                                          H   CH.sub.3                                                                             6-Br   OCH.sub.3                                                                             Cl      CH                                          H   H      5-CN   CH.sub.3                                                                              CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             6-CN   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                          H   H      5-CH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                              CH                                          H   CH.sub.3                                                                             6-CH.sub.3                                                                           CH.sub.3                                                                              Cl      CH                                          H   H      5-OCH.sub.3                                                                          CH.sub.3                                                                              OCH.sub.3                                                                             N                                           H   CH.sub.3                                                                             6-OCH.sub.3                                                                          CH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                    N                                           H   H      5-SCH.sub.3                                                                          OCH.sub.3                                                                             Cl      CH                                          H   CH.sub.3                                                                             6-SCH.sub.3                                                                          CH.sub.3                                                                              CH.sub.3                                                                              CH                                          H   H      5-OCF.sub.2 H                                                                        CH.sub.3                                                                              OCH.sub.3                                                                             CH                                          H   CH.sub.3                                                                             6-OCF.sub.2 H                                                                        OCH.sub.3                                                                             CH.sub.3                                                                              CH                                          CH.sub.3                                                                          CH.sub.3                                                                             6-Cl   CH.sub.3                                                                              Cl      CH                                          __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared inconventional ways. They include dusts, granules, pellets, solutions,suspensions, emulsions, wettable powders, emulsifiable concentrates andthe like. Many of these may be applied directly. Sprayable formulationscan be extended in suitable media and used at spray volumes of from afew liters to several hundred liters per hectare. High strengthcompositions are primarily used as intermediates for furtherformulation. The formulations, broadly, contain about 0.1% to 99% byweight of active ingredient(s) and at least one of (a) about 0.1% to 20%surfactant(s) and (b) about 1% to 99.9% solid or liquid inertdiluent(s). More specifically, they will contain these ingredients inthe following approximate proportions:

    ______________________________________                                                    Active  Weight Percent*                                                       Ingredient                                                                            Diluent(s)                                                                              Surfactant(s)                                   ______________________________________                                        Wettable Powders                                                                            20-90      0-74     1-10                                        Oil Suspensions,                                                                             3-50     40-95     0-15                                        Emulsions, Solutions,                                                         (including Emulsifiable                                                       Concentrates)                                                                 Aqueous Suspension                                                                          10-50     40-84     1-20                                        Dusts          1-25     70-99     0-5                                         Granules and Pellets                                                                        0.1-95      5-99.9  0-15                                        High Strength 90-99      0-10     0-2                                         Compositions                                                                  ______________________________________                                         *Active ingredient plus at least one of a Surfactant or a Diluent equals      100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J., but other solids, either mined or manufactured, may beused. The more absorptive diluents are preferred for wettable powdersand the denser ones for dusts. Typical liquid diluents and solvents aredescribed in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York,1950. Solubility under 0.1% is preferred for suspension concentrates;solution concentrates are preferably stable against phase separation at0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC PublishingCorp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia ofSurface Active Agents", Chemical Publishing Co., Inc., New York, 1964,list surfactants and recommended uses. All formulations can containminor amounts of additives to reduce foaming, caking, corrosion,microbiological growth, etc.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example,Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made byspraying the active material upon preformed granular carriers or byagglomeration techniques. See J. E. Browning, "Agglomeration", ChemicalEngineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer'sHandbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff.

For further information regarding the art of formulation, see forexample:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58,132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3,line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc.,New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., BlackwellScientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwiseindicated.

EXAMPLE 6

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     80%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         sodium alkylnaphthalenesulfonate                                                                          2%                                                sodium ligninsulfonate      2%                                                synthetic amorphous silica  3%                                                kaolinite                   13%                                               ______________________________________                                    

The ingredients are blended, hammer-milled until all the solids areessentially under 50 microns, reblended, and packaged.

EXAMPLE 7

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     50%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         sodium alkylnaphthalenesulfonate                                                                           2%                                               low viscosity methyl cellulose                                                                             2%                                               diatomaceous earth          46%                                               ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milledto produce particles essentially all below 10 microns in diameter. Theproduct is reblended before packaging.

EXAMPLE 8

    ______________________________________                                        Granule                                                                       ______________________________________                                        Wettable Powder of Example 7                                                                          5%                                                    attapulgite granules   95%                                                    (U.S.S. 20-40 mesh; 0.84-0.42 mm)                                             ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on thesurface of attapulgite granules in a double-cone blender. The granulesare dried and packaged.

EXAMPLE 9

    ______________________________________                                        Extruded Pellet                                                               ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     25%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         anhydrous sodium sulfate    10%                                               crude calcium ligninsulfonate                                                                              5%                                               sodium alkylnaphthalenesulfonate                                                                           1%                                               calcium/magnesium bentonite 59%                                               ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about12% water. The mixture is extruded as cylinders about 3 mm diameterwhich are cut to produce pellets about 3 mm long. These may be useddirectly after drying, or the dried pellets may be crushed to pass aU.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S.No. 40 sieve (0.42 mm openings) may be packaged for use and the finesrecycled.

EXAMPLE 10

    ______________________________________                                        Low Strength Granule                                                          ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                      0.1%                                             amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         attapulgite granules        99.9%                                             (U.S.S. 20-40 mesh)                                                           ______________________________________                                    

The active ingredient is dissolved in a solvent and the solution issprayed upon dedusted granules in a double-cone blender. After sprayingof the solution has been completed, the material is warmed to evaporatethe solvent. The material is allowed to cool and then packaged.

EXAMPLE 11

    ______________________________________                                        Granule                                                                       ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     80%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         wetting agent               1%                                                crude ligninsulfonate salt (containing                                                                    10%                                               5-20% of the natural sugars)                                                  attapulgite clay            9%                                                ______________________________________                                    

The ingredients are blended and milled to pass through a 100 meshscreen. This material is then added to a fluid bed granulator, the airflow is adjusted to gently fluidize the material, and a fine spray ofwater is sprayed onto the fluidized material. The fluidization andspraying are continued until granules of the desired size range aremade. The spraying is stopped, but fluidization is continued, optionallywith heat, until the water content is reduced to the desired level,generally less than 1%. The material is then discharged, screened to thedesired size range, generally 14-100 mesh (1410-149 microns), andpackaged for use.

EXAMPLE 12

    ______________________________________                                        Low Strength Granule                                                          ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     1%                                                amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         N,N--dimethylformamide      9%                                                attapulgite granules        90%                                               (U.S.S. 20-40 sieve)                                                          ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution issprayed upon dedusted granules in a double cone blender. After sprayingof the solution has been completed, the blender is allowed to run for ashort period and then the granules are packaged.

EXAMPLE 13

    ______________________________________                                        Aqueous Suspension                                                            ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                      40%                                              amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         polyacrylic acid thickener  0.3%                                              dodecylphenol polyethylene glycol ether                                                                   0.5%                                              disodium phosphate            1%                                              monosodium phosphate        0.5%                                              polyvinyl alcohol           1.0%                                              water                       56.7%                                             ______________________________________                                    

The ingredients are blended and ground together in a sand mill toproduce particles essentially all under 5 microns in size.

EXAMPLE 14

    ______________________________________                                        Solution                                                                      ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     5%                                                amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester, ammonium salt                                                          water                       95%                                               ______________________________________                                    

The salt is added directly to the water with stirring to produce thesolution, which may then be packaged for use.

EXAMPLE 15

    ______________________________________                                        High Strength Concentrate                                                     ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                      99%                                              amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         silica aerogel              0.5%                                              synthetic amorphous silica  0.5%                                              ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce amaterial essentially all passing a U.S.S. No. 50 screen (0.3 mmopening). The concentrate may be formulated further if necessary.

EXAMPLE 16

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                      90%                                              amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         dioctyl sodium sulfosuccinate                                                                             0.1%                                              synthetic fine silica       9.9%                                              ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produceparticles essentially all below 100 microns. The material is siftedthrough a U.S.S. No. 50 screen and then packaged.

EXAMPLE 17

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     40%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         sodium ligninsulfonate      20%                                               montmorillonite clay        40%                                               ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and thenair-milled to produce particles essentially all below 10 microns insize. The material is reblended and then packaged.

EXAMPLE 18

    ______________________________________                                        Oil Suspension                                                                ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     35%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         blend of polyalcohol carboxylic                                                                            6%                                               esters and oil soluble petroleum                                              sulfonates                                                                    xylene                      59%                                               ______________________________________                                    

The ingredients are combined and ground together in a sand mill toproduce particles essentially all below 5 microns. The product can beused directly, extended with oils, or emulsified in water.

EXAMPLE 19

    ______________________________________                                        Dust                                                                          ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     10%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         attapulgite                 10%                                               Pyrophyllite                80%                                               ______________________________________                                    

The active ingredient is blended with attapulgite and then passedthrough a hammer-mill to produce particles substantially all below 200microns. The ground concentrate is then blended with powderedpyrophyllite until homogeneous.

EXAMPLE 20

    ______________________________________                                        Oil Suspension                                                                ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     25%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         polyoxyethylene sorbitol hexaoleate                                                                        5%                                               highly aliphatic hydrocarbon oil                                                                          70%                                               ______________________________________                                    

The ingredients are ground together in a sand mill until the solidparticles have been reduced to under about 5 microns. The resultingthick suspension may be applied directly, but preferably after beingextended with oils or emulsified in water.

EXAMPLE 21

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl-                                                     20%                                               amino)carbonylamino]sulfonyl]benzoic acid, methyl                             ester                                                                         sodium alkylnaphthalenesulfonate                                                                          4%                                                sodium ligninsulfonate      4%                                                low viscosity methyl cellulose                                                                            3%                                                attapulgite                 69%                                               ______________________________________                                    

The ingredients are thoroughly blended. After grinding in a hammer-millto produce particles essentially all below 100 microns, the material isreblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) andpackaged.

Utility

Test results indicate that the compounds of the present invention areactive preemergent or postemergent herbicides or plant growth regulants.Some of them have utility for broad-spectrum pre- and/or postemergenceweed control in areas where complete control of all vegetation isdesired, such as around fuel storage tanks, ammunition depots,industrial storage areas, parking lots, drive-in theaters, aroundbillboards, highway and railroad structures. Some of the compounds haveutility for selective weed control in crops such as wheat and barley.Alternatively, the subject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention aredetermined by a number of factors, including their use as plant growthmodifiers or as herbicides, the crop species involved, the types ofweeds to be controlled, weather and climate, formulations selected, modeof application, amount of foliage present, etc. In general terms, thesubject compounds should be applied at levels of around 0.004 to 10kg/ha, the lower rates being suggested for use on lighter soils and/orthose having a low organic matter content, for plant growth modificationor for situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any othercommercial herbicide, examples of which are those of the triazine,triazole, sulfonylurea, uracil, urea, amide, diphenylether, carbamateand bipyridylium types.

The herbicidal properties of the subject compounds were discovered in anumber of greenhouse tests. The test procedures and results follow.##STR51##

TEST A

Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloacrusgalli), wild oats (Avena fatua), cheatgrass (Bromus secalinus),velvetleaf (Abutilon theophrasti), morningglory (Ipomoea spp.),cocklebur (Xanthium pensylvanicum), sorghum, corn, soybean, sugarbeet,cotton, rice, wheat, barley and purple nutsedge (Cyperus rotundus)tubers were planted and treated preemergence with the test chemicalsdissolved in a non-phytotoxic solvent. At the same time, these crop andweed species were treated with a soil/foliage application. At the timeof treatment, the plants ranged in height from 2 to 18 cm. Treatedplants and controls were maintained in a greenhouse for sixteen days,after which all species were compared to controls and visually rated forresponse to treatment. The ratings, summarized in Table A, are based ona numerical scale extending from 0=no injury, to 10=complete kill. Theaccompanying descriptive symbols have the following meanings:

C=chlorosis/necrosis;

B=burn;

D=defoliation;

E=emergence inhibition;

G=growth retardation;

H=formative effect;

U=unusual pigmentation;

X=axillary stimulation;

S=albinism; and

6Y=abscised buds or flowers.

                                      TABLE A                                     __________________________________________________________________________            Compound 1                                                                            Compound 2                                                                            Compound 3                                                                             CMPD 4  CMPD 5  CMPD 6  CMPD 7               Rate kg/ha                                                                            0.05                                                                              0.4 0.05                                                                              0.4 0.05 0.4 0.05                                                                              0.4 0.05                                                                              0.4 0.05                                                                              0.4 0.05                                                                             0.4               __________________________________________________________________________    POSTEMERGENCE                                                                 Cotton  6G  9C  9C  10C 3C,6G                                                                              9C  6G  10C 8G  9C  2G  3C,8G                                                                             0  0                 Morningglory                                                                          3C,8G                                                                             10C 4C,9G                                                                             10C 3C,7G                                                                              2C,9G                                                                             3C,7G                                                                             9C  2C,8G                                                                             9C  2G  3C,8G                                                                             0  0                 Cocklebur                                                                             5G  10C 5C,9G                                                                             10C 2H,7G                                                                              10C 8G  10C 8G  10C 4G  5H  0  2G                Nutsedge                                                                              3C,8G                                                                             9C  9C  9C  0    2C,5G                                                                             3G  2C,9G                                                                             2G  9C  0   7G  0  0                 Crabgrass                                                                             5G  9G  6G  4C,8G                                                                             0    3C,7G                                                                             4G  2C,8G                                                                             0   9C  0   3C,9G                                                                             0  0                 Barnyardgrass                                                                         3C,8H                                                                             6C,9H                                                                             4C,8H                                                                             9C  2C,5H                                                                              4C,9G                                                                             9C  5C,9G                                                                             2G  9C  2H  5C,9G                                                                             0  0                 Wild Oats                                                                             3G  2C,8G                                                                             3C,9G                                                                             4C,9G                                                                             0    9G  9G  3C,9G                                                                             2C,9G                                                                             2C,9G                                                                             2C,9G                                                                             9C  0  0                 Wheat   2G  2C,9G                                                                             5C,9G                                                                             9C  8G   9G  5G  7G  7G  2C,9G                                                                             9G  9C  0  0                 Corn    8H  9G  2U,9G                                                                             10C 2U,9G                                                                              3U,9G                                                                             4G  7G  6G  7G  3G  3C,9G                                                                             0  3G                Soybean 4C,9G                                                                             5C,9G                                                                             9C  9C  4C,9G                                                                              5C,9G                                                                             4C,9G                                                                             9C  4C,9G                                                                             6C,9G                                                                             3C,8G                                                                             4C,9G                                                                             0  1C                Rice    5C,9G                                                                             6C,9G                                                                             5C,9G                                                                             9C  9C   9C  5C,9G                                                                             10C 4C,9G                                                                             5C,9G                                                                             5C,9G                                                                             9C  0  0                 Sorghum 3C,9G                                                                             3C,9G                                                                             9C  9C  4C,9G                                                                              4C,9G                                                                             3C,9G                                                                             4C,9G                                                                             4C,9H                                                                             9C  2C,5G                                                                             4C,8H                                                                             0  0                 Cheatgrass                                                                            4C,9G                                                                             9C  10C 9C  3C,9G                                                                              9C  2C,8G                                                                             9C  8G  9C  9G  9C  0  6G                Sugar beet                                                                            3C,8G                                                                             10C 10C 10C 3C,8H                                                                              10C 6G  10C 3C,8H                                                                             9C  2C,2H                                                                             9C  0  0                 Velvetleaf                                                                            8G  10C 7G  4C,9G                                                                             4G   2C,8G                                                                             5G  6C,9G                                                                             7G  8G  2G  3G  0  0                 Giant Foxtail                                                                         3C,6G                                                                             6C,9G                                                                             3C,5G                                                                             9C  0    5G  4G  7G  0   5G  6G  10C 0  0                 Barley  0   6G  9C  6C,9G                                                                             0    4G  8G  8G  7G  4C,9G                                                                             3C,7G                                                                             3C,9G                                                                             0  0                 PREEMERGENCE                                                                  Cotton  7G  9G  9G  9G  5G   7G  5G  9G  2C,5G                                                                             9G  2G  7G  0  2G                Morningglory                                                                          5G  9G  9H  9G  3C,6G                                                                              8G  8G  10E 8G  9G  3G  5G  0  0                 Cocklebur                                                                             0   7G  4G  9H  1H   8H  2H  9H  9H  9H  --  3G  0  --                Nutsedge                                                                              9G  10E 10E 10E 10E  10E 9G  10E 9G  10E 0   10E 0  0                 Crabgrass                                                                             2G  8G  7G  10E 0    3C,7G                                                                             2G  2C,5G                                                                             0   2C,8G                                                                             0   4G  0  0                 Barnyardgrass                                                                         3C,8H                                                                             3C,9H                                                                             7H  9H  1C   9H  7G  9H  5G  9H  2G  8H  0  0                 Wild Oats                                                                             5G  2C,7G                                                                             4C,8G                                                                             3C,9H                                                                             0    2C,6G                                                                             2C,6G                                                                             2C,8G                                                                             5G  3C,7H                                                                             0   2C,6G                                                                             0  0                 Wheat   5G  3C,8G                                                                             2C,8G                                                                             3C,9H                                                                             0    3C,8H                                                                             2G  2C,7G                                                                             5G  9H  0   9H  0  0                 Corn    3C,8G                                                                             9H  3C,9H                                                                             10E 3C,9G                                                                              9G  2C,6G                                                                             2C,9G                                                                             3C,3G                                                                             9G  3C,5G                                                                             9G  0  0                 Soybean 3C,3G                                                                             4C,9H                                                                             9H  9H  2H   3C,7H                                                                             9H  9H  8H  9H  2C  3C,7H                                                                             0  0                 Rice    10E 10E 10E 10E 10E  10E 9H  10E 10E 10E 9H  10E 0  0                 Sorghum 4C,9H                                                                             10H 5C,9H                                                                             10E 9H   10E 3C,8H                                                                             4C,9H                                                                             3C,9H                                                                             5C,9H                                                                             2C  3C,8H                                                                             0  0                 Cheatgrass                                                                            9H  10E 9H  9H  9H   9H  8H  9H  9H  9H  5G  10E 0  0                 Sugar beet                                                                            8G  9G  9G  3C,9G                                                                             9G   9G  9G  9G  9G  9G  3H  2C,8G                                                                             0  5G                Velvetleaf                                                                            1H  3C,8G                                                                             7G  3C,9G                                                                             3G   3G  2G  8G  3G  8G  0   2C  0  0                 Giant Foxtail                                                                         4G  3C,8G                                                                             3G  8H  0    0   0   2G  0   3G  0   8H  0  0                 Barley  2G  3C,7G                                                                             3C,9H                                                                             4C,9H                                                                             1C   9G  8G  2C,9H                                                                             8G  3C,9H                                                                             2C  9H  0  0                 __________________________________________________________________________                              CMPD 8  CMPD 9 CMPD 10                                                                              CMPD 11 CMPD 12                                 Rate kg/ha                                                                            0.05                                                                              0.4 0.05                                                                             0.4 0.05                                                                             0.4 0.05                                                                              0.4 0.05                                                                             0.4                __________________________________________________________________________                      POSTEMERGENCE                                                                 Cotton  2C,8G                                                                             4C,9G                                                                             0  0   0  5G  2C,5G                                                                             10C 0  0                                    Morningglory                                                                          3C,8H                                                                             9C  0  2G  0  0   2H  5C,9G                                                                             0  0                                    Cocklebur                                                                             8H  10C 0  2G  0  1C  2H  4C,8H                                                                             0  0                                    Nutsedge                                                                              5G  3C,9G                                                                             0  0   0  0   0   3G  0  --                                   Crabgrass                                                                             8G  9G  0  0   0  2G  0   3G  0  0                                    Barnyardgrass                                                                         5C,9G                                                                             9C  0  0   0  0   5H  9C  0  0                                    Wild Oats                                                                             2C,8G                                                                             5C,9G                                                                             0  6G  0  0   3G  8G  0  0                                    Wheat   8G  6C,9G                                                                             0  4G  0  0   9G  9C  0  0                                    Corn    9H  3U,9G                                                                             0  2G  0  0   2G  2C,8G                                                                             0  0                                    Soybean 4C,9G                                                                             9C  0  2G  0  2C,5H                                                                             3C,9G                                                                             5C,9G                                                                             0  2C,5H                                Rice    9C  9C  0  2C,3G                                                                             0  8G  3C,6G                                                                             5C,9G                                                                             0  5G                                   Sorghum 3C,9G                                                                             6C,9G                                                                             0  0   0  5G  2C,7G                                                                             2C,9G                                                                             0  0                                    Cheatgrass                                                                            9C  9C  0  3G  0  3G  9G  5C,9G                                                                             0  0                                    Sugar beet                                                                            3C,7G                                                                             9C  0  3G  0  2H  3C,6G                                                                             9C  0  3G                                   Velvetleaf                                                                            4G  4C,9G                                                                             0  0   0  0   0   6G  0  3G                                   Giant Foxtail                                                                         3C,8G                                                                             9C  0  0   0  6G  3G  2C,7G                                                                             0  2G                                   Barley  4C,9G                                                                             6C,9G                                                                             0  0   0  0   3G  2C,8G                                                                             0  0                                    PREEMERGENCE                                                                  Cotton  7G  9G  0  0   0  2G  8G  4G  0  0                                    Morningglory                                                                          9G  9G  0  0   0  0   0   8G  0  0                                    Cocklebur                                                                             8G  --  0  0   -- 2G  0   5G  0  0                                    Nutsedge                                                                              9G  10E 0  0   0  0   4G  9G  0  0                                    Crabgrass                                                                             3G  3C,6G                                                                             0  0   0  0   0   4G  0  0                                    Barnyardgrass                                                                         7H  9H  0  0   0  2C  1C  9H  0  0                                    Wild Oats                                                                             2G  3C,7H                                                                             0  0   0  0   3G  2C,6G                                                                             0  0                                    Wheat   8H  9H  0  0   0  0   0   7G  0  0                                    Corn    9G  9H  0  0   0  0   2C,4G                                                                             8G  0  0                                    Soybean 9H  9H  0  0   0  3G  2C,2H                                                                             8H  0  0                                    Rice    10H 10E 0  0   0  0   2C,8G                                                                             10E 0  3G                                   Sorghum 3C,9H                                                                             5C,9H                                                                             0  0   0  0   3C,3G                                                                             3C,9H                                                                             0  0                                    Cheatgrass                                                                            8H  9H  0  0   0  2G  7G  10E 0  0                                    Sugar beet                                                                            8G  9G  0  0   0  0   7G  9G  0  3G                                   Velvetleaf                                                                            0   2C,8G                                                                             0  0   0  0   0   5G  0  2G                                   Giant Foxtail                                                                         0   6G  0  0   0  0   0   3C,6G                                                                             0  0                                    Barley  9H  5C,9H                                                                             0  0   0  0   5G  8G  0  0                  __________________________________________________________________________

TEST B Postemergence

Three round pans (25 cm diameter by 12.5 cm deep) were filled withSassafras sandy loam soil. One pan was planted with nutsedge (Cyperusrotundus) tubers, crabgrass (Digitaria sanquinalis), sicklepod (Cassiaobtusifolia), jimsonweed (Datura stramonium), velvetleaf (Abutilontheophrasti), lambsquarters (Chenopodium album), rice (Oryza sativa) andteaweed (Sida spinosa). The second pot was planted with green foxtail(Setaria viridis), cocklebur (Xantium pensylvanicum), morningglory(Ipomoea hederacea), cotton (Gossypium hirsutum), johnsongrass (Sorghumhalepense), barnyardgrass (Echinochloa crusgalli), corn (Zea mays),soybean (Glycine max) and giant foxtail (Setaria faberi). The third potwas planted with wheat (Triticum aestivum), barley (Hordeum vulgare),wild buckwheat (Polgonum convolvulus L.), cheatgrass (Bromus secalinusL.), sugarbeet (Beta vulgaris), wild oats (Avena fatua), viola (Violaarvensis), blackgrass (Alopecurus myosuroides), and rape (Brassicanapus). The plants were grown for approximately fourteen days, thensprayed postemergence with the chemicals dissolved in a non-phytotoxicsolvent.

Preemergence

Three round pans (25 cm diameter by 12.5 cm deep) were filled withSassafras sandy loam soil. One pan was planted with nutsedge tubers,crabgrass, sicklepod, jimsonweed, velvetleaf,, lambsquarters, rice andteaweed. The second pot was planted with green foxtail, cocklebur,morningglory, cotton, johnsongrass, barnyardgrass, corn, soybean andgiant foxtail. The third pot was planted with wheat, barley, wildbuckwheat, cheatgrass, sugarbeet, wild oat, viola, blackgrass and rape.The three pans were sprayed preemergence with the chemicals dissolved ina non-phytotoxic solvent.

Treated plants and controls were maintained in the greenhouse for 24days, then all rated plants were compared to controls and visually ratedfor plant response.

Response ratings are based on a scale of 0 to 100 where 0=no effect and100=complete control. A dash (--) response means no test.

Response ratings are contained in Table B.

                                      TABLE B                                     __________________________________________________________________________                CMPD 1      CMPD 2                                                RATE RATE = G/HA                                                                          0016                                                                              0062                                                                              0250                                                                              0004                                                                              0016                                                                              0062                                                                             0250                                       __________________________________________________________________________    POSTEMERGENCE                                                                 GIANT FOXTAIL                                                                             30  40      0   0   30                                            VELVETLEAF  30  50  70  30  50  70 100                                        SUGAR BEETS 50  70      50  70  100                                           CRABGRASS   50  60  70  50  60  70 90                                         TEAWEED     30  40  50  30  50  70 90                                         JIMSONWEED  30  50  70  30  50  70 100                                        RICE        90  100 100 80  90  100                                                                              100                                        COCKLEBUR   20  30  40  30  50  70 90                                         COTTON      0   30  40  20  30  60 80                                         SOYBEAN     30  50      60  70  80                                            BARNYARD GRASS                                                                            30  40  50  30  50  70 90                                         WILD OATS   0   30      30  50  60                                            MORNINGGLORY                                                                              0   0   0   30  50  70 100                                        WHEAT       0   30      20  40  100                                           CASSIA      40  50  60  30  60  100                                                                              100                                        JOHNSONGRASS                                                                              50  60  70  80  90  100                                                                              100                                        NUTSEDGE    30  50  70  0   30  70 100                                        CORN        20  30      0   20  60                                            WILD BUCKWHEAT                                                                            0   30      0   30  60                                            BLACK GRASS 0   30      30  50  70                                            RAPESEED    30  50      50  70  100                                           BARLEY      0   30      20  60  100                                           GREEN FOXTAIL                                                                             30  40  60  0   30  50 80                                         CHEAT GRASS 30  50      50  70  100                                           BUCKWHEAT                                                                     VIOLA       0   0       0   30  40                                            LAMBSQUARTER                                                                              50  60  70  50  70  90 100                                        __________________________________________________________________________                CMPD 1         CMPD 2                                             RATE RATE = G/HA                                                                          0016                                                                             0062                                                                             0250                                                                             0500                                                                             1000                                                                             0004                                                                             0016                                                                             0062                                                                             0250                                      __________________________________________________________________________    PREEMERGENCE                                                                  GIANT FOXTAIL                                                                             0  30 50 70 80 0  0  30 70                                        VELVETLEAF  30 50 70 80 90 30 50 60 80                                        SUGAR BEETS 80 90 100                                                                              100                                                                              100                                                                              70 80 90 100                                       CRABGRASS   30 50 70 90 90 30 50 70 90                                        TEAWEED     40 50 60 70 80 30 50 70 90                                        JIMSONWEED  90 90 100                                                                              100                                                                              100                                                                              50 70 80 90                                        RICE        100                                                                              100                                                                              100                                                                              100                                                                              100                                                                              100                                                                              100                                                                              100                                                                              100                                       COCKLEBUR   0  0  20 40 60 30 50 60 80                                        COTTON      0  20 40 50 60 20 30 50 80                                        SOYBEAN     0  30 60 70 80 40 60 80 90                                        BARNYARD GRASS                                                                            30 50 60 70 80 30 60 90 100                                       WILD OATS   0  30 50 60 70 30 50 70 90                                        MORNINGGLORY                                                                              0  20 30 40 50 30 50 70 100                                       WHEAT       20 30 40 60 80 30 50 70 100                                       CASSIA      70 80 100                                                                              100                                                                              100                                                                              70 80 90 100                                       JOHNSONGRASS                                                                              30 40 50 60 70 30 60 90 100                                       NUTSEDGE    30 50 70 90 100                                                                              100                                                                              100                                                                              100                                                                              100                                       CORN        0  20 60 70 80 30 60 80 100                                       WILD BUCKWHEAT                                                                            30 40 50 60 70 30 50 70 90                                        BLACK GRASS 40 50 60 70 80 50 70 90 100                                       RAPESEED    70 80 90 100                                                                              100                                                                              90 100                                                                              100                                                                              100                                       BARLEY      0  20 40 60 80 50 70 90 100                                       GREEN FOXTAIL                                                                             0  30 50 70 100                                                                              0  30 60 90                                        CHEAT GRASS 40 50 70 80 90 50 70 90 100                                       BUCKWHEAT                                                                     VIOLA       30 50 70 90 100                                                                              0  30 50 80                                        LAMBSQUARTER                                                                              50 60 70 80 90 30 50 70 90                                        __________________________________________________________________________

What is claimed is:
 1. A compound of the formula: ##STR52## wherein R isH or CH₃ ;X is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, NH₂, NHCH₃ or N(CH₃)₂ ; Yis H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₂ alkylthio, Cl or Br; Z is CH,CF, CCl or CBr; J is ##STR53## R₁ is F, Cl, Br, NO₂, C₁ -C₄ alkyl, C₁-C₄ haloalkyl, C₃ -C₄ cycloalkyl, C₂ -C₄ haloalkenyl, C₁ -C₄ alkoxy, C₁-C₄ haloalkoxy, C₂ -C₄ alkoxyalkoxy, CO₂ R_(a), C(O)NR_(b) R_(c), SO₂NR_(d) R_(e), S(O)_(n) R_(f), C(O)R_(g), CH₂ CN or L; R₂ is H, F, Cl,Br, CN, CH₃, OCH₃, SCH₃ or OCF₂ H; R₃ is Cl, NO₂, CO₂ CH₃, CO₂ CH₂ CH₃,SO₂ N(CH₃)₂, SO₂ CH₃, SO₂ CH₂ CH₃, OCH₃ or OCH₂ CH₃ ; R_(a) is C₁ -C₃alkyl optionally substituted by halogen, C₁ -C₂ alkoxy or CN, allyl orpropargyl; R_(b) is H, C₁ -C₃ alkyl or C₁ -C₂ alkoxy; R_(c) is C₁ -C₂alkyl; R_(d) is H, C₁ -C₃ alkyl, C₁ -C₂ alkoxy, allyl or cyclopropyl;R_(e) is H or C₁ -C₃ alkyl; R_(f) is C₁ -C₃ alkyl, C₁ -C₃ haloalkyl,allyl or propargyl; R_(g) is C₁ -C₄ alkyl, C₁ -C₄ haloalkyl or C₃ -C₅cycloalkyl optionally substituted by halogen; n is 0, 1 or 2; L is##STR54## R_(h) is H or CH₃ ; R_(i) is H or CH₃ ; R_(j) is H, CH₃ or CH₂CH₃ ; R_(k) is H, CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, SCH₃ or SCH₂ CH₃ ; R_(m)is H, CH₃ or CH₂ CH₃ ; R_(n) is H or CH₃ ; R₄ is C₁ -C₃ alkyl, C₁ -C₂haloalkyl, C₁ -C₂ alkoxy, C₂ -C₄ haloalkenyl, F, Cl, Br, NO₂, CO₂ R_(a),C(O)NR_(b) R_(c), SO₂ NR_(d) R_(e), S(O)_(n) R_(f), C(O)R_(g) or L; R₅is H, F, Cl, Br or CH₃ ; R₆ is C₁ -C₃ alkyl, C₁ -C₂ alkoxy, C₂ -C₄haloalkenyl, F, Cl, Br, CO₂ R_(a), C(O)NR_(b) R_(c), SO₂ NR_(d) R_(e),S(O)_(n) R_(f), C(O)R_(g) or L; R₇ is H, F, Cl or CH₃ ; R₈ is H or C₁-C₃ alkyl; R₉ is C₁ -C₃ alkyl, C₁ -C₂ alkoxy, F, Cl, Br, NO₂, CO₂ R_(a),SO₂ NR_(d) R_(e), S(O)_(n) R_(f), OCF₂ H, C(O)R_(g), C₂ -C₄ haloalkenylor L; R₁₀ is H, Cl, F, Br, C₁ -C₃ alkyl or C₁ -C₂ alkoxy; R₁₁ is H or C₁-C₂ alkyl; R₁₂ is H or C₁ -C₂ alkyl; R₁₃ is H, C₁ -C₆ alkyl, C₁ -C₄haloalkyl, C₂ -C₄ alkoxyalkyl, C₃ -C₅ cycloalkyl or C₄ -C₆cycloalkylalkyl; R₁₄ is H, F, Cl, Br, CN, CH₃, OCH₃, SCH₃ or OCF₂ H; andQ is O, S, SO, SO₂ or C(O);and their agriculturally suitable salts;provided that X and Y are not simultaneously H.
 2. The compounds ofclaim 1 whereX is CH₃, CH₂ CH₃, OCH₃ or OCH₂ CH₃ ; and Y is CH₃, CH₂CH₃, OCH₃, OCH₂ CH₃, SCH₃, SCH₂ CH₃, Cl or Br.
 3. The compounds of claim2 whereR₁ is Cl, NO₂, CH₃, CH₂ CH₃, C₁ -C₂ haloalkyl, cyclopropyl, C₂-C₃ haloalkenyl, OCH₃, OCH₂ CH₃, C₁ -C₂ haloalkoxy, CO₂ R_(a),C(O)NR_(b) R_(c), SO₂ NR_(d) R_(e), S(O)_(n) R_(f), C(O)R_(g), CH₂ CN orL; R_(b) is H, CH₃ or OCH₃ ; R_(c) is CH₃ ; R_(d) is H, CH₃ or OCH₃ ;R_(e) is CH₃ ; R_(f) is CH₃ or CH₂ CH₃ ; R_(g) is CH₃, CH₂ CH₃ orcyclopropyl; n is O or 2; R₄ is CH₃, CH₂ CH₃, Cl, Br, NO₂, CO₂ R_(a),C(O)NR_(b) R_(c), SO₂ NR_(d) R_(e), S(O)_(n) R_(f) or C(O)R_(g) ; R₅ isH; R₆ is CH₃, CH₂ CH₃, OCH₃, Cl, Br, CO₂ R_(a), C(O)NR_(b) R_(c), SO₂NR_(d) R_(e), S(O)_(n) R_(f) or C(O)R_(g) ; R₇ is H; R₈ is CH₃ ; R₉ isCH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, Cl, Br, NO₂, CO₂ R_(a), SO₂ NR_(d) R_(e)or S(O)_(n) R_(f) ; R₁₀ is H, Cl, CH₃ or OCH₃ ; R₁₁ is H or CH₃ ; R₁₂ isH; and R₁₃ is H or C₁ -C₄ alkyl.
 4. Compounds of claim 3 where J is J-1.5. Compounds of claim 3 where J is J-2.
 6. Compounds of claim 3 where Jis J-3.
 7. Compounds of claim 3 where J is J-4.
 8. Compounds of claim 3where J is J-5.
 9. Compounds of claim 3 where J is J-6.
 10. Compounds ofclaim 3 where J is J-7.
 11. Compounds of claim 3 where J is J-8. 12.Compounds of claim 3 where J is J-9.
 13. Compounds of claim 3 where J isJ-10.
 14. Compounds of claim 3 where J is J-11.
 15. Compounds of claim 3where J is J-12.
 16. Compounds of claim 3 where J is J-13.
 17. Compoundsof claim 3 where J is J-14.
 18. Compounds of claim 3 where J is J-15.19. Compounds of claim 3 where J is J-16.
 20. The compound of claim 1which is2-[[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinylamino)carbonylamino]sulfonyl]benzoicacid, methyl ester.
 21. The compound of claim 1 which is2-chloro-N-[(6-chloro-3,4-dihydro-4-methyl-3-oxo-2-pyrazinyl)aminocarbonyl]benzenesulfonamide.22. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 1and at least one of the following: surfactant, solid or liquid diluent.23. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 2and at least one of the following: surfactant, solid or liquid diluent.24. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 3and at least one of the following: surfactant, solid or liquid diluent.25. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 4and at least one of the following: surfactant, solid or liquid diluent.26. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 5and at least one of the following: surfactant, solid or liquid diluent.27. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 6and at least one of the following: surfactant, solid or liquid diluent.28. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 7and at least one of the following: surfactant, solid or liquid diluent.29. A method for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 1. 30. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 2. 31. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound of claim3.
 32. A method for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 4. 33. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 5. 34. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound of claim6.
 35. A method for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim 7.